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Combinatorial multicomponent access to natural-products-inspired peptidomimetics: discovery of selective inhibitors of microbial metallo-aminopeptidases

ChemMedChem

Jul 6, 2014

Yanira MéndezDaniel G Rivera

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Abstract

The development of selective inhibitors of microbial metallo-aminopeptidases is an important goal in the pursuit of antimicrobials for therapeutic applications. Herein, we disclose a combinatorial approach relying on two Ugi reactions for the generation of peptidomimetics inspired by na...read more

Mentioned in this Paper

Natural Products
Aminopeptidase
Metalloproteins
Structure of Cortex of Kidney
Recombinants
Metabolic Inhibition
Microbial
Family suidae
Microbicides
Escherichia coli
1
23
Paper Details
References
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  • References48
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Combinatorial multicomponent access to natural-products-inspired peptidomimetics: discovery of selective inhibitors of microbial metallo-aminopeptidases

ChemMedChem

Jul 6, 2014

Yanira MéndezDaniel G Rivera

PMID: 24989844

DOI: 10.1002/cmdc.201402140

Abstract

The development of selective inhibitors of microbial metallo-aminopeptidases is an important goal in the pursuit of antimicrobials for therapeutic applications. Herein, we disclose a combinatorial approach relying on two Ugi reactions for the generation of peptidomimetics inspired by na...read more

Mentioned in this Paper

Natural Products
Aminopeptidase
Metalloproteins
Structure of Cortex of Kidney
Recombinants
Metabolic Inhibition
Microbial
Family suidae
Microbicides
Escherichia coli
1
23

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

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Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

Journal of Enzyme Inhibition and Medicinal Chemistry

Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors(opens in new tab)

Journal of Enzyme Inhibition and Medicinal ChemistryMarch 18, 2008
Mange R YadavRobert Menard
Paper Details
References
  • References48
  • Citations4
12345
  • References48
  • Citations4

Download from

Publisher
PubMed
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