Combinatorial prospects of nano-targeted chemoimmunotherapy

Biomaterials
C G Da SilvaLuis J Cruz

Abstract

Despite the significant increase in our knowledge on cancer initiation and progression, and the development of novel cancer treatments, overall patient survival rates have thus far only marginally improved. However, it can be expected that lasting tumor control will be attainable for an increasing number of cancer patients in the foreseeable future, which is likely to be achieved by combining cancer chemotherapy with anticancer immunotherapy. A plethora of new cancer chemotherapy reagents are expected to become accessible to the clinic in the coming years which can then be used for efficient tumor debulking and aid in antigen exposure to the immune system. Durable remission and the eradication of micrometastases are likely to be achieved with specialized monoclonal antibodies and therapeutic cancer vaccines that modulate the immune system to overcome immunosuppression and kill distant cancer cells. Moreover, the method of drug delivery to tumors, stromal and immune cells is expected to shift largely from conventional 'free' drug molecules to encapsulated in targeted nano-vehicles, therapeutics often referred to or considered part of "nanomedicine". Several biocompatible nano-vehicles, such as metal-nanoparticles, biodegradable-...Continue Reading

References

Sep 1, 1991·The Journal of Experimental Medicine·P S LinsleyJ A Ledbetter
Jan 1, 1994·Annual Review of Immunology·J BanchereauS Saeland
Jan 1, 1993·Annual Review of Immunology·P S Linsley, J A Ledbetter
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·M OtsujiT Saito
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·L A DoyleD D Ross
Apr 20, 2000·The Journal of Clinical Investigation·D HanahanE Bergsland
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S A KusmartsevS H Chen
Oct 4, 2000·Journal of Pharmaceutical Sciences·B StellaP Couvreur
Feb 13, 2001·Vaccine·P Moingeon
Feb 21, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·K AvgoustakisD S Ithakissios
Mar 27, 2002·Nature Reviews. Immunology·Pramod Srivastava
Nov 14, 2002·Bioscience Reports·Ghania Chikh, Marie-Paule Schutze-Redelmeier
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna K NowakBruce W S Robinson
Jun 18, 2003·Trends in Immunology·Vincenzo BrontePaola Zanovello
Dec 20, 2003·Cancer Immunology, Immunotherapy : CII·Theresa L Whiteside, Christine Odoux
May 26, 2004·Cancer Letters·D Patrick O'NealJennifer L West
Jul 22, 2004·International Journal of Pharmaceutics·Jundong DaiQiang Zhang
Aug 3, 2004·Nature Medicine·Anne O'Garra, Paulo Vieira
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Sharon A OldfordSheila Drover
Aug 2, 2005·Nature Reviews. Immunology·Vincenzo Bronte, Paola Zanovello
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eiji SuzukiSteven M Albelda
Dec 21, 2005·The Journal of Experimental Medicine·Noelia CasaresGuido Kroemer
Jan 13, 2006·International Journal of Cancer. Journal International Du Cancer·Donald Maxwell Parkin
May 30, 2006·Advances in Immunology·Charles G DrakeDrew M Pardoll
Jun 13, 2006·The Journal of Clinical Investigation·Alexandra Zanin-ZhorovIrun R Cohen
Jul 11, 2006·Immunological Reviews·Christopher A KlebanoffNicholas P Restifo
Dec 14, 2006·International Journal of Cancer. Journal International Du Cancer·Pauline VerdijkI Jolanda M de Vries
Dec 26, 2006·Nature Medicine·Michel ObeidGuido Kroemer
Jan 16, 2007·American Journal of Reproductive Immunology : AJRI·Rui ChenGil Mor
Apr 19, 2007·Cancer Immunology, Immunotherapy : CII·Ji-Yan LiuYi-Xin Zeng
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pratima SinhaSuzanne Ostrand-Rosenberg
Aug 29, 2007·Cancer Immunology, Immunotherapy : CII·Weihsu ChenLeaf Huang

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Citations

May 29, 2016·Cancer Letters·Yong XinGuan Jiang
Jul 3, 2016·Drug Discovery Today·Maria Chatzinikolaidou
Nov 4, 2016·Neurochemical Research·Arundhati JoshiRalf Dringen
Jul 30, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Flavia FontanaHélder A Santos
Sep 10, 2017·Cancer Chemotherapy and Pharmacology·C G Da SilvaLuis J Cruz
Jan 16, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yu-Qing XieLi Tang
Oct 11, 2017·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Yuriy K Bashmakov, Ivan M Petyaev
Jan 29, 2019·Current Topics in Medicinal Chemistry·Junfu ZhangJun Pang
Nov 7, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zhaogang YangBetty Y S Kim
Jan 17, 2019·Oxidative Medicine and Cellular Longevity·Yu-Guo YuanIl-Keun Kong
Jul 23, 2020·Frontiers in Pharmacology·Chen QianHong Cui
Apr 3, 2019·Advanced Science·Yu MiAndrew Z Wang
Oct 26, 2018·International Journal of Molecular Sciences·Ding-Ping BaiXi-Feng Zhang
Jul 14, 2019·Seminars in Cancer Biology·Balney RajithaGanji Purnachandra Nagaraju
Jan 14, 2021·Artificial Cells, Nanomedicine, and Biotechnology·Xiangcai ZouZonghai Huang
Aug 6, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jian XuJiwen Zhang
Nov 27, 2020·Frontiers in Chemistry·Cerise M SiamofWeibo Cai
Nov 8, 2020·Pharmaceutics·Zili GuLuis J Cruz
Feb 22, 2021·Drug Discovery Today·Sarwar BegHani Choudhry
Jan 29, 2020·Analytica Chimica Acta·Magdalena FlontZbigniew Brzózka
Apr 2, 2021·Expert Opinion on Drug Delivery· Neha DesaiAbdelwahab Omri
Apr 19, 2021·Journal of Nanobiotechnology·Rafieh BagherifarYousef Javadzadeh
May 18, 2021·Acta Pharmaceutica Sinica. B·Qingqing XiaoWei He
Jun 18, 2021·Nano-micro Letters·Weiwei MuNa Zhang
Jul 24, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Christine E BooneNicole F Steinmetz
Jun 9, 2018·ACS Nano·Pingqiang CaiXiaodong Chen
Sep 7, 2019·ACS Applied Materials & Interfaces·Tianyi KangMaling Gou

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