Combinatorial techniques for enhancing neuroprotection: hypothermia and alkalinization

Annals of the New York Academy of Sciences
Damien P Kuffler

Abstract

Brain and spinal cord (CNS) trauma typically kill a number of neurons, but even more neurons are killed by secondary causes triggered by the initial trauma. Thus, a minor insult may rapidly cause the death of a vastly larger number of neurons and complete paralysis. The best mechanism for reducing the extent of neurological deficits is to minimize the number of neurons killed by post-trauma sequelae. Neuroprotection techniques take many diverse forms with a breadth too great for a short review. Therefore, this review focuses on the neuroprotection provided by hypothermia and a number of other neuroprotective techniques, when administered singly or in combination, because it is generally found that combinations of applications lead to significantly better neuroprotection than is achieved by any one alone. The combinatorial approach to neuroprotection holds great promise for enhancing the degree of neuroprotection following trauma, leading to maximum maintenance of neurological function.

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Citations

May 2, 2012·Therapeutics and Clinical Risk Management·Damien P Kuffler
Jul 7, 2012·AJNR. American Journal of Neuroradiology·P D PurdyM S Riegel
Jul 28, 2015·International Journal of Molecular Sciences·Jiaqiong Wang, Damien D Pearse
Oct 12, 2021·Physiology·Torkjel Tveita, Gary C Sieck

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