Combinatorial therapeutic approaches with RNAi and anticancer drugs using nanodrug delivery systems

Drug Development and Industrial Pharmacy
Anish BabuRajagopal Ramesh

Abstract

RNA interference (RNAi) is emerging as a powerful approach in cancer treatment. siRNA is an important RNAi tool that can be designed to specifically silence the expression of genes involved in drug resistance and chemotherapeutic inactivity. Combining siRNA and other therapeutic agents can overcome the multidrug resistance (MDR) phenomenon by simultaneously silencing genes and enhancing chemotherapeutic activity. Moreover, the therapeutic efficiency of anticancer drugs can be significantly improved by additive or synergistic effects induced by siRNA and combined therapies. Co-delivery of these diverse anticancer agents, however, requires specially designed nanocarriers. This review highlights the recent trends in siRNA/anticancer drug co-delivery systems under the major categories of liposomes/lipid, polymeric and inorganic nanoplatforms. The objective is to discuss the strategies for nanocarrier-based co-delivery systems using siRNA/anticancer drug combinations, emphasizing various siRNA targets that help overcome MDR and enhance therapeutic efficiency.

References

Feb 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D L Dexter, J T Leith
Nov 27, 1999·Journal of Microencapsulation·A Namdeo, N K Jain
Oct 18, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·R Krishna, L D Mayer
May 3, 2003·Nature Reviews. Genetics·Clare E ThomasMark A Kay
Jul 18, 2006·Current Medicinal Chemistry·Ricardo Pérez-Tomás
Nov 15, 2006·Journal of Biomedical Science·Chih-Ping MaoT-C Wu
Mar 7, 2007·Expert Review of Anticancer Therapy·John S Vorhies, John Nemunaitis
Jul 11, 2007·Journal of Materials Science. Materials in Medicine·Yongzhuo HuangWenquan Liang
Jan 31, 2009·Nature Reviews. Drug Discovery·Kathryn A WhiteheadDaniel G Anderson
Nov 26, 2009·Biochimica Et Biophysica Acta·Andriy Marusyk, Kornelia Polyak
Dec 2, 2009·Methods in Molecular Biology·Jean-Pierre Gillet, Michael M Gottesman
Jul 8, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yunching ChenLeaf Huang
Aug 4, 2010·Journal of Radiation Research·Mamta D NaiduLouis A Peña
Sep 30, 2010·Nanomedicine·Atsushi Tamura, Yukio Nagasaki
Feb 16, 2011·International Journal of Pharmaceutics·Amir Khashayar VarkouhiGert Storm
May 28, 2011·CA: a Cancer Journal for Clinicians·Patrizia AgostinisJakub Golab
Jun 16, 2012·Mini Reviews in Medicinal Chemistry·Wu JunYao Juming
Aug 17, 2012·Molecular Pharmaceutics·Dong ZhaoSi-Xue Cheng
Aug 21, 2012·International Journal of Nanomedicine·Wen-Pin SuWu-Chou Su
Oct 11, 2012·Immunotherapy·Soudeh Ghafouri-Fard, Somayyeh Ghafouri-Fard
Nov 10, 2012·Biomaterials·Swati BiswasVladimir P Torchilin
Nov 28, 2012·Advanced Healthcare Materials·Xing MaYanli Zhao
Jan 19, 2013·International Journal of Pharmaceutics·Kyuri LeeJi Hoon Jeong
Mar 20, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy A YapJohann S de Bono
Jun 19, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuan ZhangLeaf Huang
Jul 23, 2013·Nature·Natalia L Komarova, C Richard Boland
Sep 18, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Lorena TavanoNevio Picci
Oct 15, 2013·Chemistry : a European Journal·Xing MaYanli Zhao
Oct 24, 2013·Nature Materials·Rosemary KanastyDaniel Anderson
Feb 11, 2014·Nature Chemical Biology·Daniel C Sévin, Uwe Sauer
Mar 7, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ya DingVincent M Rotello

❮ Previous
Next ❯

Citations

Sep 13, 2018·Current Medicinal Chemistry·Annamaria Sandomenico, Menotti Ruvo
Jun 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Florian GauthierFrançoise Debart
Apr 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Giacomo BiagiottiPaolo Paoli
Nov 12, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Vignesh KumarRaghuraman Kannan
Nov 7, 2019·Chemistry and Physics of Lipids·Marcel ScheidelerRuth Prassl
Mar 21, 2021·Molecular Cancer·Parvez KhanMohd Wasim Nasser
Jul 18, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Saikat GhoshSubhas Bhowmick
Aug 25, 2021·The International Journal of Biochemistry & Cell Biology·R Viswambari DeviMukesh Doble

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.