Combinatorial treatments enhance recovery following facial nerve crush

The Laryngoscope
Nijee SharmaEileen M Foecking

Abstract

To investigate the effects of various combinatorial treatments, consisting of a tapering dose of prednisone (P), a brief period of nerve electrical stimulation (ES), and systemic testosterone propionate (TP) on improving functional recovery following an intratemporal facial nerve crush injury. Prospective, controlled animal study. After a right intratemporal facial nerve crush, adult male Sprague-Dawley rats were divided into the following eight treatment groups: 1) no treatment, 2) P only, 3) ES only, 4) ES + P, 5) TP only, 6) TP + P, 7) ES + TP, and 8) ES + TP + P. For each group n = 4-8. Recovery of the eyeblink reflex and vibrissae orientation and movement were assessed. Changes in peak amplitude and latency of evoked response, in response to facial nerve stimulation, was also recorded weekly. : Brief ES of the proximal nerve stump most effectively accelerated the initiation of functional recovery. Also, ES or TP treatments enhanced recovery of some functional parameters more than P treatment. When administered alone, none of the three treatments improved recovery of complete facial function. Only the combinatorial treatment of ES + TP, regardless of the presence of P, accelerated complete functional recovery and return of ...Continue Reading

References

Jan 1, 1996·Annals of Internal Medicine·S MurakamiN Yanagihara
Jun 23, 2004·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Marcus OhlssonMikael Svensson
Jun 23, 2005·Journal of Reconstructive Microsurgery·Ning-jiang ShenJi Cai
Apr 5, 2008·Hormones and Behavior·Keith N FargoKathryn J Jones
Jul 1, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Laura E T HetzlerEileen M Foecking
Jul 5, 2008·Endocrinology·Weidong ZhaoChristopher P Cardozo
Dec 17, 2008·Neurological Research·T GordonK M Chan
Sep 1, 2009·The Laryngoscope·Nijee SharmaEileen M Foecking
Jan 1, 2010·Restorative Neurology and Neuroscience·Nijee SharmaEileen M Foecking

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Citations

Dec 1, 2011·Neurologia i neurochirurgia polska·Przemysław KunertAndrzej Marchel
Jan 13, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tessa Gordon
Aug 2, 2013·Restorative Neurology and Neuroscience·Gina N MonacoEileen M Foecking
May 2, 2015·The Journal of Craniofacial Surgery·Mehmet Akif YildirimAbdulvahap Akyigit
Jan 12, 2017·The Annals of Otology, Rhinology, and Laryngology·Steven J CharousEileen M Foecking
Jun 21, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Muhamad AmineSam J Marzo
Nov 16, 2017·Plastic and Reconstructive Surgery·Carrie A KubiakStephen W P Kemp
Jun 30, 2015·The European Journal of Neuroscience·Tessa Gordon, Arthur W English
Oct 5, 2019·Regenerative Medicine·Yun QianCunyi Fan
Feb 26, 2020·The Laryngoscope·Lauren WelbyTeresa E Lever
Jan 29, 2019·Frontiers in Cellular Neuroscience·Claire Emma McGregor, Arthur W English
Jul 1, 2020·Laryngoscope Investigative Otolaryngology·Brandon L BrownChandler L Walker

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