Combined 123I-FP-CIT and 123I-IBZM SPECT for the diagnosis of parkinsonian syndromes: study on 72 patients

Journal of Neural Transmission
M PlotkinS Venz

Abstract

72 consecutive patients with suspected parkinsonian syndromes (PS) were studied by dopamine transporter (DAT) and D2 receptor SPECT in order to evaluate the accuracy of combined SPECT imaging. In the follow-up, the patients were diagnosed as having Parkinson's disease (PD, n = 25), dementia with Lewy bodies (DLB, n = 6), multiple system atrophy (MSA, n = 13), progressive supranuclear palsy (PSP, n = 8), corticobasal degeneration (CBD, n = 9), and essential tremor (ET, n = 11). Using the iteratively estimated optimal cutoffs, DAT was reduced in 57/61 PS patients, whereas all ET patients were identified as "normal". Reduced D2 receptor binding had 7/13 patients with MSA, 6/8 patients with PSP, 2/9 patients with CBD and no ET, PD or DLB patients. FP-CIT SPECT allows an accurate detection of nigrostriatal affection in neurodegenerative PS. IBZM SPECT is useful to approve the diagnosis of PSP and MSA although a normal finding cannot exclude an atypical PS. IBZM SPECT seems to be of restricted value in CBD.

Citations

May 28, 2009·Journal of Neurology·Gregor K Wenning, Nadia Stefanova
Mar 24, 2005·Journal of Neural Transmission·K R KesslerG Auburger
May 3, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Georges El FakhriNathaniel M Alpert
Aug 24, 2011·International Psychogeriatrics·Zuzana Walker, Joanne Rodda
Aug 4, 2011·Brain : a Journal of Neurology·Jeffrey L CummingsPaul Kemp
Aug 29, 2013·Nuclear Medicine Communications·Susanne NikolausHans-Wilhelm Müller
May 10, 2012·Journal of Biomedicine & Biotechnology·Lie-Hang ShenYu-Chin Tseng
Sep 4, 2007·BMC Neurology·Annemarie M M VlaarWim E J Weber
Aug 13, 2013·PloS One·Alisdair McNeillAnthony H V Schapira
Oct 16, 2010·Biomarkers in Medicine·David J Brooks
Nov 12, 2014·Nature Reviews. Neurology·Marios Politis
Oct 29, 2013·BioMed Research International·Susanna Jakobson MoKatrine Riklund
Jul 24, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Valentina BertiSandro Sorbi
Apr 15, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Ralph BuchertMalte Clausen
Oct 20, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Koen Van LaereJacques Darcourt
May 2, 2007·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Richard Camicioli, Serge Gauthier
May 5, 2011·Journal of Biomedicine & Biotechnology·Lie-Hang ShenYing-Kai Fu
Jan 25, 2013·Journal of Neural Transmission·Elisabeth FunkeMichail Plotkin
Sep 8, 2012·Journal of Neurology·Matej KolencMaja Trošt
Jan 25, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Klaus Tatsch
Jul 25, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Kenji IshibashiKenji Ishii
Jul 2, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Susanna Jakobson MoKatrine Riklund
Dec 18, 2008·Expert Review of Neurotherapeutics·Angelo Antonini, Ioannis U Isaias
Jan 24, 2016·Ageing Research Reviews·David J Brooks
Jan 20, 2016·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Kazuo WashidaTatsushi Toda
Sep 18, 2012·Drug Discovery Today·Jian WangJing Zhang
Sep 8, 2011·Progress in Neurobiology·David J Brooks, Nicola Pavese
Jun 12, 2010·Parkinsonism & Related Disorders·Joseph H Friedman
Sep 9, 2009·Clinical Neurology and Neurosurgery·Carsten FinkeUwe Reuter
Jun 16, 2009·Behavioural Brain Research·Susanne NikolausHans-Wilhelm Müller
Mar 24, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·David J BrooksUNKNOWN Neuroimaging Working Group on MSA
Mar 5, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel G HealyAndrew J Lees
Oct 1, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Sean S O'SullivanAndrew J Lees
Dec 11, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Florian DoeppStephan J Schreiber
Apr 3, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Sabina PappatàAlfredo Postiglione
Oct 5, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Eduardo TolosaUNKNOWN DaTSCAN Clinically Uncertain Parkinsonian Syndromes Study Group
May 9, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Christoph ScherflerWerner Poewe
Jul 2, 2011·Annals of the New York Academy of Sciences·Valentina BertiLisa Mosconi
Dec 15, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J C BeuckeA Kupsch
Jan 13, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Elmar LobsienFlorian Doepp

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