PMID: 2124191Sep 1, 1990Paper

Combined 5-fluorouracil, adriamycin and mitomycin C in the management of adenocarcinoma metastasizing to the liver from an unknown primary site

The Journal of International Medical Research
H Y al-Idrissi

Abstract

A combination of 5-fluorouracil, adriamycin and mitomycin was used to treat patients with adenocarcinoma metastasizing only to the liver from an unknown primary site. Of the 29 evaluable patients, only three (10.3%) achieved short partial remission for 6-12 weeks and two (6.9%) patients were stabilized for 4 weeks. The partial responders demonstrated a short survival time of 10-22 weeks and the median survival of non-responders was 8 weeks, which was not significantly different from that of responders. It is concluded that, although treatment of patients with metastatic adenocarcinoma of unknown primary site should be individualized, in general systemic chemotherapy for patients presenting with liver metastases is probably not justified.

References

Nov 1, 1979·Current Problems in Cancer·E T KrementzL R Morgan
Apr 1, 1978·American Journal of Surgery·R T OsteenR E Wilson
Mar 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R M GoldbergP S Schein
Mar 15, 1982·Cancer·P Chang, W H Knapper
Dec 1, 1981·Southern Medical Journal·S R IndupalliG P Bodey

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Citations

Feb 21, 2007·Expert Opinion on Pharmacotherapy·Anne C Armstrong, Fiona H Blackhall
Jun 15, 2007·Acta Oncologica·Nicholas Pavlidis
Feb 16, 2005·Current Problems in Surgery·Luna GhoshBimal C Ghosh

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