Combined Abciximab REteplase Stent Study in acute myocardial infarction (CARESS in AMI)

American Heart Journal
Carlo Di MarioPhilippe Gabriel Steg

Abstract

Most patients with acute myocardial infarction (AMI) are admitted to hospitals without percutaneous transluminal coronary angioplasty (PTCA) facilities or are initially managed in a prehospital mobile unit. Thrombolysis remains the most readily available reperfusion treatment in those settings, but the optimal subsequent strategy in those patients is unclear. If a mechanical recanalization is likely to be performed in an emergency, it is probably desirable that the patient receives abciximab, the glycoprotein IIb/IIIa antagonist with the strongest evidence of benefit for angioplasty in AMI. The aim of this trial is to compare the effects on clinical outcome and cost-effectiveness of 2 strategies after immediate treatment with abciximab and half-dose reteplase for ST-elevation AMI: to manage the patients conservatively (referring them for rescue PTCA only if needed) or to immediately send all patients for emergency coronary angioplasty. The Combined Abciximab RE-teplase Stent Study in Acute Myocardial Infarction (CARESS in AMI) is an open, prospective, randomized, multicenter clinical trial conducted in patients with high-risk ST-segment elevation AMI treated within 12 hours from symptom onset in hospitals without PTCA facilitie...Continue Reading

Associated Clinical Trials

References

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Citations

Dec 7, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Warren J CantorLaurie J Morrison
Dec 31, 2008·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Gerald S WernerUNKNOWN EuroCTO Club
Jun 8, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Julien RosencherUNKNOWN OPTIMAL investigators
Mar 17, 2007·Scandinavian Cardiovascular Journal : SCJ·Ellen BøhmerSigrun Halvorsen
Feb 19, 2008·Lancet·Nicolas Danchin, Paul W Armstrong
Jul 21, 2007·The Medical Clinics of North America·Richard J Gumina
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Aug 2, 2005·Journal of the American College of Cardiology·Michel R Le MayLyall A Higginson
Mar 25, 2014·Circulation·Peter R Sinnaeve, Frans Van de Werf
Jan 23, 2008·Journal of Cardiovascular Pharmacology·Marco ZimarinoRaffaele De Caterina
Jul 26, 2005·QJM : Monthly Journal of the Association of Physicians·G De LucaM Chiariello

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