PMID: 9172828Jan 1, 1997Paper

Combined action of inhibitors of S-adenosylmethionine decarboxylase with an antimalarial drug, chloroquine, on Plasmodium falciparum

The Journal of Eukaryotic Microbiology
B DasR Madhubala

Abstract

Methylglyoxal bis (guanylhydrazone), (MGBG) a potent competitive inhibitor of S-adenosyl-L-methionine decarboxylase activity, Berenil, a trypanocidal agent and chloroquine, the commonly used antimalarial resulted in a dose dependent inhibition of Plasmodium falciparum in vitro. The IC50 values of MGBG, Berenil and chloroquine were 224 microM, 40 microM and 42 nM respectively. Parasites treated with different concentrations of MGBG or Berenil were arrested at the trophozoite stage of the erythrocytic cycle. The combined action of chloroquine (10 nM) with either Berenil (0.1 mM) or MGBG (0.1 mM) on P. falciparum growth showed an additive inhibitory effect. The effect of these inhibitors alone and in combination on polyamine biosynthesis is also reported.

References

Dec 1, 1979·Experimental Parasitology·U BachrachC L Greenblatt
Aug 20, 1976·Science·W Trager, J B Jensen
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T A Shapiro, P T Englund
May 1, 1986·Biochemical Pharmacology·R Balaña-FouceA Garrido-Pertierra
Jan 14, 1972·Biochemical and Biophysical Research Communications·H G Williams-Ashman, A Schenone
Nov 1, 1982·The American Journal of Physiology·A E Pegg, P P McCann

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Citations

Jul 30, 2005·Expert Opinion on Investigational Drugs·M N C SoeiroD W Boykin
May 23, 2020·Research Quarterly for Exercise and Sport·Mandy S PlumbAmanda Timler

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