PMID: 11907387Mar 22, 2002Paper

Combined administration of diltiazem and nicardipine attenuates hypertensive responses to emergence and extubation

Journal of Neurosurgical Anesthesiology
Toshinori Tsutsui

Abstract

Diltiazem and nicardipine, when injected as a mixture during anesthesia, reduce blood pressure in an additive manner without changing heart rate. The author evaluated the use of this mixture for controlling the blood pressure during emergence from general anesthesia and at extubation. The subjects included 15 preoperative hypertensive (HT) patients who underwent various types of surgery and 18 patients with subarachnoid hemorrhage (SAH) who underwent clipping of a cerebral aneurysm. General anesthesia was maintained with isoflurane or sevoflurane, supplemented with fentanyl. A mixed solution containing 2.5 mg diltiazem plus 0.5 mg nicardipine in 1 mL was injected intermittently every 2 to 4 minutes to bring the blood pressure to its resting level from cessation of inhaled anesthetics to extubation. Untreated patients who underwent similar types of surgery and anesthesia were selected for comparison. The average systolic blood pressure during emergence and at extubation increased to 156 +/- 19 mm Hg (mean +/- standard deviation) and 170 +/- 10 mm Hg in the untreated HT group, and increased to 157 +/- 16 mm Hg and 170 +/- 5mm Hg in the untreated SAH group. Systolic blood pressure was well controlled at 127 +/- 14 mm Hg and 145 +/...Continue Reading

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References

Jan 1, 1975·British Journal of Anaesthesia·T J Gal, L H Cooperman
Sep 1, 1978·Canadian Anaesthetists' Society Journal·A V BidwaiV A Bidwai
Mar 1, 1992·British Journal of Anaesthesia·A LowrieS L Robinson
Jul 1, 1991·Anesthesia and Analgesia·R PaulissianH J Heyman
Dec 1, 1990·Anesthesia and Analgesia·A DysonJ M Lipton
Oct 25, 1990·The New England Journal of Medicine·D A Calhoun, S Oparil
Jan 1, 1989·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S EliaD Lappas
Sep 1, 1988·Neurosurgery·I H Kalfas, J R Little
Oct 1, 1987·Anesthesia and Analgesia·G WallinT Hedner
May 1, 1983·The American Journal of Cardiology·M S SmithE L Pritchett
Jun 1, 1982·Acta Anaesthesiologica Scandinavica·U M Kautto
Jul 1, 1980·Canadian Anaesthetists' Society Journal·R HodgkinsonR H Hayashi
Jul 1, 1995·Acta Anaesthesiologica Scandinavica·K NishinaH Obara
Jun 1, 1995·Anesthesia and Analgesia·K NishinaH Obara
Jan 1, 1995·Anesthesia and Analgesia·K A MillerP L Bailey
Oct 1, 1993·British Journal of Anaesthesia·M Hartley, R S Vaughan

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