Combined administration of PTX and S-HM-3 in TPGS/Solutol micelle system for oncotarget therapy

International Journal of Nanomedicine
Weiguang LiHanmei Xu

Abstract

S-HM-3 is a tumor angiogenesis inhibitor with short half-life (25 min). In this present, TPGS/Solutol polymeric micelles was prepared to load together insoluble paclitaxel (PTX) and soluble S-HM-3, expecting to together deliver them to the tumor site with long-circulating, targeting function and combating multi-drug resistance (MDR). PTX and S-HM-3 loaded TPGS/Solutol micelles (PHTSm) were prepared by the method of thin-film evaporation, and characterized by dynamic light scattering, transmission electron microscope (TEM), atomic force microscopy (AFM) and releasing properties. The anticancer effect of the polymeric micelles system was evaluated and confirmed by experiments of in vitro cell uptake study, in vivo pharmacokinetics, and pharmacodynamics studies. Micelles exhibited smooth spherical morphology with 20~30 nm and low critical micelle concentration (CMC) value of 0.000124 mg/mL. Only about 30% of PTX were slowly released from micelles at 48h, which can beneficial to the long circulation in blood. The results of in vitro cell assay proved that S-HM-3 could be easier to get into MDA-MB-231 cell, and its angiogenesis inhibition ability was also enhanced after integrating into micelles. In particular, the results of in viv...Continue Reading

Citations

Nov 26, 2020·International Journal of Molecular Sciences·Andrzej KubiakMałgorzata Lekka

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Methods Mentioned

BETA
atomic force microscopy
ELISA
fluorescence imaging
AFM
flow cytometry
xenograft

Software Mentioned

SPSS
Carestream Molecular
Image pro - plus

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