Combined adrenal myelolipoma and adenoma associated with Cushing's syndrome

American Journal of Clinical Pathology
M Vyberg, L Sestoft

Abstract

A case of Cushing's syndrome in a 31-year-old woman is presented. The resected left adrenal gland revealed a tumor consisting of cortical cells intermingled with myelolipomatous tissue comparable to that of normal bone marrow. The adjacent cortex was atrophic. Postoperative plasma cortisol concentrations have remained quite low. Previously, 28 cases of surgically removed adrenocortical tumors with a main diagnosis of myelolipoma have been published. Of these, three cases (two pituitary Cushing's disease, one steroid 21-hydroxylase deficiency) were associated with endocrine dysfunction. The combination of a myelolipoma and a true adenoma has only been described once before (in a case of virilization) and never in connection with Cushing's syndrome. The etiology of myelolipoma is discussed, and a local trigger mechanism related to adrenocortical growth disturbances is suggested.

Citations

Jan 1, 1992·Cytopathology : Official Journal of the British Society for Clinical Cytology·E BeleziniS Markidou
Sep 15, 2004·Pathology International·Takaharu MatsudaKoichi Suda
Feb 5, 2014·International Journal of Surgical Pathology·José Manuel Suárez-PeñarandaJosé Ignacio Muñoz-Barús
Mar 1, 1992·Acta Pathologica Japonica·T ItoS Aizawa
Feb 7, 2004·International Journal of Surgical Pathology·Ray ArmandJohn C Papadimitriou
Apr 5, 2003·Pathology International·Youhei MasugiMasaru Murai
Dec 31, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rana F AmmouryEwa Elenberg
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·K Y Lam
Feb 1, 1996·Australasian Radiology·F BayramE Evcik
May 21, 1999·Radiographics : a Review Publication of the Radiological Society of North America, Inc·P OtalF Joffre
May 12, 2004·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Chiara CaliumiClaudio Letizia
Sep 1, 1989·The Japanese Journal of Surgery·T TanakaN Takeyama
Oct 1, 1996·Endocrine Pathology·Mauro PapottiGianni Bussolati
Mar 18, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kathleen T MontoneVirginia A Livolsi
Jun 11, 2008·Journal of Zhejiang University. Science. B·Hong-sheng LuShan-qiang Huang
Jan 9, 2021·Case Reports in Endocrinology·Cathy ZhouMichael J Campbell
Jul 23, 2003·Archives of Pathology & Laboratory Medicine·Albert Y ChuPaul J Zhang
Jun 14, 2021·Pathology, Research and Practice·Katrina CollinsLiang Cheng
Jul 24, 2004·Magnetic Resonance Imaging Clinics of North America·Hero K Hussain, Melvyn Korobkin
Sep 18, 2010·Pathology, Research and Practice·Sohsuke YamadaYasuyuki Sasaguri

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