Combined alcoholic and non-alcoholic steatohepatitis

JHEP Reports : Innovation in Hepatology
Line Carolle Ntandja WandjiAlexandre Louvet

Abstract

While metabolic syndrome and alcohol consumption are the two main causes of chronic liver disease, one of the two conditions is often predominant, with the other acting as a cofactor of morbimortality. It has been shown that obesity and alcohol act synergistically to increase the risk of fibrosis progression, hepatic carcinogenesis and mortality, while genetic polymorphisms can strongly influence disease progression. Based on common pathogenic pathways, there are several potential targets that could be used to treat both diseases; based on the prevalence and incidence of these diseases, new therapies and clinical trials are needed urgently.

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Citations

Sep 26, 2020·Frontiers in Medicine·Francisco IdalsoagaJuan Pablo Arab
Sep 25, 2020·Clinical and Molecular Hepatology·Jong Hwa ChoiYong Kyun Cho
Oct 15, 2020·Biomolecules·Mohamed ElnagdyLeila Gobejishvili
Dec 18, 2020·Frontiers in Oncology·Diwakar SureshDivya P Kumar
Mar 16, 2021·Terapevticheskiĭ arkhiv·K L RaikhelsonE V Pazenko
Jun 3, 2021·International Journal of Molecular Sciences·Szu-Yi LiuYin-Chou Hsu
Jun 11, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Xinting PanXian-E Peng
Jun 19, 2021·Hepatology Communications·Raquel Benedé-UbietoYulia A Nevzorova
Aug 17, 2021·Archives of Physiology and Biochemistry·Elham Karimi-SalesMohammad Reza Alipour

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Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT02039219

Software Mentioned

REGENERATE

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