Combined Aliskiren and L-arginine treatment reverses renovascular hypertension in an animal model

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Renata V TiradentesS A Gouvêa

Abstract

Renovascular hypertension is characterized by increased renal sympathetic activity, angiotensin II and by endothelial dysfunction. The purpose of this study was to determine the role of renal sympathetic nerve activity (RSNA) in mediating the anti-hypertensive effects of aliskiren (ALSK) and L-arginine (L-ARG) in a rat renovascular hypertension model. Hypertension was induced by clipping the right renal artery, and the following five groups were divided: SHAM operated; 2-kidney, 1-clip (2K1C); 2K1C plus ALSK; 2K1C plus L-ARG; and 2K1C plus ALSK+ L-ARG. The systolic blood pressure (SBP) of 2K1C rats increased from 114.4±5.2 to 204±12.7 mm Hg (P<0.05) and was only reduced by ALSK+L-ARG treatment (138.4±4.37 mm Hg). The 2K1C hypertension increased the baseline RSNA (SHAM: 62.4±6.39 vs. 2K1C: 97.4±8.43%). L-ARG or ALSK+L-ARG treatment significantly decreased baseline RSNA (2K1C L-ARG:70.7±2.39; 2K1C ALSK+L-ARG: 69.3±4.23%), but ALSK treatment alone did not (2K1C ALSK: 84.2±2.5%). Urinary water, Na(+), Cl(-) and urea excretion were similar in the 2K1C L-ARG, 2K1C ALSK+L-ARG and SHAM groups. The combination of ALSK+L-ARG restored urine flow and increased the glomerular filtration rate. The nNOS expression in the non clipped kidney wa...Continue Reading

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Citations

Jan 26, 2016·Clinical and Experimental Pharmacology & Physiology·Yue GuYong Ji
Jul 8, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Vinicius MengalSonia A Gouvea
Jul 22, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Makiko OboshiTohru Masuyama
Mar 10, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mahboobeh Yeganeh-HajahmadiFarzaneh Rostamzadeh
Apr 3, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Danielle A Guimaraes, Jose E Tanus-Santos

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