Combined analog and action potential coding in hippocampal mossy fibers

Science
Henrik Alle, Jörg R P Geiger

Abstract

In the mammalian cortex, it is generally assumed that the output information of neurons is encoded in the number and the timing of action potentials. Here, we show, by using direct patchclamp recordings from presynaptic hippocampal mossy fiber boutons, that axons transmit analog signals in addition to action potentials. Excitatory presynaptic potentials result from subthreshold dendritic synaptic inputs, which propagate several hundreds of micrometers along the axon and modulate action potential-evoked transmitter release at the mossy fiber-CA3 synapse. This combined analog and action potential coding represents an additional mechanism for information transmission in a major hippocampal pathway.

References

Feb 12, 1990·Brain Research·M D MuñozE García-Austt
Aug 18, 1995·Science·R J DouglasH H Suarez
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·P A SalinR A Nicoll
Apr 5, 2003·Current Biology : CB·Uri Werner-ReissJennifer M Groh
Jun 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stefan HallermannManfred Heckmann
Sep 16, 2003·Neuron·Arnaud RuizDimitri M Kullmann
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Carl C H PetersenBert Sakmann
Apr 27, 2004·Nature·Christoph Schmidt-HieberJosef Bischofberger

❮ Previous
Next ❯

Citations

Jun 28, 2006·Pflügers Archiv : European journal of physiology·Josef BischofbergerPeter Jonas
Sep 3, 2010·Pflügers Archiv : European journal of physiology·Itzchak Parnas, Hanna Parnas
Jul 19, 2006·Cell and Tissue Research·Paulo Pinheiro, Christophe Mulle
Aug 26, 2006·Cell and Tissue Research·Astrid Rollenhagen, Joachim H R Lübke
Jul 27, 2012·Neuroscience Bulletin·Wenqin Hu, Yousheng Shu
Apr 8, 2009·Nature Neuroscience·Kenneth Paradiso, Ling-Gang Wu
Jan 19, 2010·Nature Neuroscience·Joana LourençoGiovanni Marsicano
Dec 21, 2010·Nature Neuroscience·Jason M ChristieCraig E Jahr
Aug 1, 2006·Nature Neuroscience·Kirill E VolynskiDimitri M Kullmann
Sep 12, 2009·Science·Henrik AlleJörg R P Geiger
Feb 5, 2011·Science·Takuya SasakiYuji Ikegaya
Jun 16, 2012·Science·Tamar DugladzeTengis Gloveli
May 20, 2011·Journal of Neurophysiology·Colin G EvansElizabeth C Cropper
Jul 17, 2009·Journal of Neurophysiology·Bjoern Ch LudwarElizabeth C Cropper
Feb 22, 2012·Neural Development·Michael P SceniakShasta L Sabo
Jan 28, 2014·PLoS Computational Biology·Biswa SenguptaJeremy Edward Niven
May 3, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sam A BookerImre Vida
Aug 1, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ricardo ScottDmitri A Rusakov
Oct 5, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·YunXiang ChuWade G Regehr
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Esther Krook-MagnusonIvan Soltesz
Jul 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Colin G EvansElizabeth C Cropper
Sep 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason M Christie, Craig E Jahr
Sep 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuguo YuDavid McCormick
Oct 28, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amanda J FoustDavid A McCormick
Dec 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ricardo ScottDmitri A Rusakov
Jan 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julia J Harris, David Attwell
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shunbing ZhaoFarzan Nadim
Nov 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason R Pugh, Craig E Jahr
Feb 29, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel J Brasier, Daniel E Feldman
Jan 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason R Pugh, Craig E Jahr
Apr 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·János BrunnerJános Szabadics
Jan 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sina TootoonianMala Murthy
Mar 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Geeta SharmaSukumar Vijayaraghavan
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·János SzabadicsIvan Soltesz
May 29, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason B Castro, Nathaniel N Urban
May 25, 2013·Psychonomic Bulletin & Review·Daniel YurovskyLinda B Smith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.