Combined analysis identifies six genes correlated with augmented malignancy from non-small cell to small cell lung cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Cheng ZhangChengchao Shou

Abstract

With increased malignancy, lung cancer can be classified into adenocarcinoma (ADC), squamous cell carcinoma (SQC), large cell carcinoma (LCC), and the small cell subtype (SCLC); yet, elucidations to this augmented malignancy has not been addressed. In this study, we elucidated the molecular diversity among these subtypes by investigating large-scale sequencing datasets. Among genes upregulated from normal, ADC, SQC, LCC to SCLC, six hub genes were found closely correlated with adverse clinical outcome and were testified on cellular or tissue level with quantitative RT-PCR. Cox regression model was then built to generate a risk signature. The possible linkages among these genes were also explored. Transcript levels of BUB1, E2F1, ESPL1, GTSE1, RAB3B, and U2AF2 were found significantly elevated from normal, ADC, SQC, LCC to SCLC. Overexpression of one or multiple of these genes was correlated with adverse overall survival (OS) and relapse-free survival (RFS) in the whole patient cohort or groups stratified according to clinical variables, while most of all six genes were independent prognostic factors. When used as a six-gene risk signature, patients with high signature score displayed more unfavorable clinical variables and poor...Continue Reading

References

Dec 21, 1978·The New England Journal of Medicine·B J McNeilS G Pauker
May 1, 1986·Chest·D J AdelsteinJ D Hines
Sep 1, 1993·Epidemiology·K T HegmannJ L Lyon
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D F CellaJ Brannon
Feb 21, 1996·Journal of the National Cancer Institute·E A Zang, E L Wynder
Jun 1, 1997·Chest·C F Mountain, C M Dresler
Apr 1, 1998·Nature·D P CahillB Vogelstein
May 30, 1998·Journal of the National Cancer Institute·T R HolfordS T Mayne
Feb 17, 2000·The EMBO Journal·M A Martínez-BalbásT Kouzarides
Aug 15, 2000·Clinical Oncology : a Journal of the Royal College of Radiologists·N O'Rourke, R Edwards
Feb 7, 2002·The European Respiratory Journal·E BrambillaY Shimosato
Mar 20, 2003·Journal of the National Cancer Institute·Peter B BachColin B Begg
Apr 1, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Suneel D Mundle, Gurveen Saberwal
May 17, 2003·The Journal of Biological Chemistry·Martin MonteClaudio Schneider
Oct 1, 2005·Nature Reviews. Cancer·Geert J P L KopsDon W Cleveland
Jan 5, 2007·The New England Journal of Medicine·Hsuan-Yu ChenPan-Chyr Yang
Nov 23, 2007·Current Opinion in Cell Biology·Phillip J Iaquinta, Jacqueline A Lees
Dec 7, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cheng-long HuangHiromi Wada
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Nenggang ZhangDebananda Pati
Jun 3, 2009·The Journal of Cell Biology·Christiane KlebigPatrick Meraldi
Sep 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Liyun ZouYuzhang Wu
Sep 26, 2009·BMC Bioinformatics·Hsun-Hsien Chang, Marco F Ramoni
Sep 25, 2009·Nature Reviews. Cancer·Shirley Polager, Doron Ginsberg
Jul 7, 2010·Molecular Cell·Haroula Kontaki, Iannis Talianidis
Sep 15, 2010·Cancer·Hsun-Hsien ChangMarco F Ramoni
Mar 5, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Pier Luigi FilossoAlberto Oliaro
Mar 25, 2011·Science Translational Medicine·Lecia V SequistJeffrey A Engelman
Dec 21, 2011·Molecular and Cellular Biology·Jasmyne CarnevaleFrederick A Dick
May 1, 2012·Archives of Pathology & Laboratory Medicine·Philip T Cagle, Lucian R Chirieac
May 24, 2013·Science Translational Medicine·Sophie RousseauxSaadi Khochbin
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
May 23, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Erick RiquelmeIgnacio I Wistuba
Oct 20, 2014·Nature Structural & Molecular Biology·Changwei ShaoXiang-Dong Fu

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Citations

Jul 8, 2018·International Journal of Cancer. Journal International Du Cancer·Giorgia SimonettiGiovanni Martinelli
Nov 21, 2019·Genes·Eugenia BezzecchiRoberto Mantovani
Jul 12, 2019·Scientific Reports·Shreshtha MalviaSunita Saxena
Sep 26, 2017·Molecular Medicine Reports·Junqiang DaiYawen Pan
Jun 22, 2020·Journal of Applied Genetics·Raneem Y HammouzAndrzej K Bednarek
Sep 14, 2021·Frontiers in Genetics·Zhendong LiuYanzheng Gao

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