Combined Analysis of Biparametric MRI and Prostate-Specific Antigen Density: Role in the Prebiopsy Diagnosis of Gleason Score 7 or Greater Prostate Cancer

AJR. American Journal of Roentgenology
Sue Ji LeeSung Yoon Park

Abstract

The objective of our study was to investigate the diagnostic performance of prebiopsy biparametric MRI (bpMRI) and prostate-specific antigen density (PSAD) for Gleason score (GS) 7 or greater prostate cancer (PCa). Sixty-eight consecutive patients who underwent prebiopsy bpMRI and biopsy were included. Pathologic results of systemic and targeted biopsies were the reference standard. Qualitative analyses comprised Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) and modified PI-RADSv2 (mPI-RADSv2). Quantitative analyses comprised mean apparent diffusion coefficient (ADC) of tumor, 10th percentile ADC of tumor, mean ADC ratio (ADCR) between benign tissues and PCa, and 10th percentile ADCR between benign tissues and PCa. The AUCs of the following combined models for GS 7 or greater PCa were investigated: model 1, PSAD and PI-RADSv2; model 2, PSAD and mPI-RADSv2; model 3, PSAD and mean ADC; model 4, PSAD and 10th percentile ADC; model 5, PSAD and mean ADCR; and model 6, PSAD and 10th percentile ADCR. The rate of GS 7 or greater PCa was 45.6% (31/68). AUCs of bpMRI parameters were 0.816 for PI-RADSv2, 0.838 for mPI-RADSv2, 0.820 for mean ADC, 0.823 for 10th percentile ADC, 0.780 for mean ADCR, and 0.763 for 10th perc...Continue Reading

References

Dec 20, 2002·AJR. American Journal of Roentgenology·Stephen J Karlik
Oct 22, 2008·Radiology·Makoto SasakiUNKNOWN Acute Stroke Imaging Standardization Group-Japan (ASIST-Japan) Investigators
May 15, 2012·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Joseph H YacoubOto Aytekin
Jun 16, 2012·European Urology·Marc A Dall'EraMark S Soloway
Mar 21, 2015·AJR. American Journal of Roentgenology·Cher Heng TanVikas Kundra
Apr 15, 2016·AJR. American Journal of Roentgenology·Sungmin WooSeung Hyup Kim
Oct 27, 2016·Journal of Magnetic Resonance Imaging : JMRI·Jung Jae Park, Byung Kwan Park
Apr 5, 2017·The Journal of Urology·Florian A DistlerBoris A Hadaschik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.