Combined analysis of differentiation inhibitory factor nm23-H1 and nm23-H2 as prognostic factors in acute myeloid leukaemia

British Journal of Cancer
N WakimotoY Honma

Abstract

Differentiation inhibitory factor (nm23 protein) inhibited the induction of the differentiation of various leukaemic cell lines. We previously reported that nm23 genes (H1 and H2) were overexpressed in acute myelogenous leukaemia (AML) and nm23-H1 expression predicted the prognosis of AML, especially AML-M5. To clarify the correlation between French-American-British (FAB) classification and nm23 expression level and to clarify the involvement of nm23-H2 and nm23-H1 in patient survival, we investigated the relative levels of nm23-H1 and -H2 mRNA in 76 AML samples using the reverse transcriptase-polymerase chain reaction. We confirmed that the expression of both nm23-H1 and -H2 genes in AML samples from three different hospitals was significantly higher than that in normal blood cells (P < 0.0005). Overexpression of nm23-H1 was observed in each FAB AML-M1, -M2, -M3, -M4 or -M5 subtype, and the predictive effect of nm23-H1 expression on AML prognosis was shown in FAB AML-M2 and -M5 cases. Although overexpression of nm23-H2 was also found in each FAB subtype, the expression of nm23-H2 in AML-M1 and -M3 cells was not significantly higher than that in normal cells. Among AML subtypes, AML-M3 showed the lowest expression levels of bot...Continue Reading

Citations

Nov 5, 2016·Bioscience Reports·Zhenhua ZhouJianru Xiao
Oct 17, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Patrizia RomaniValeria Cavaliere
Sep 24, 2011·Advances in Hematology·Junko Okabe-KadoYasuhiko Kaneko
Aug 3, 2002·Leukemia & Lymphoma·Junko Okabe-Kado
Aug 15, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·A Joshua LillyChristopher M Bunce

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