Combined androgen blockade: an update

The Urologic Clinics of North America
Laurence Klotz

Abstract

The use of combined androgen blockade therapy in prostate cancer management remains controversial. This article reviews the effect of the different non-steroid androgens in blocking androgen-independent activation of the androgen receptor in the androgen-depleted environment, and the potential benefit of bicalutamide in comparison to the first generation of anti-androgens (flutamide and nilutamide). An estimate of the benefit of combined therapy with bicalutamide suggests there is a high probability that bicalutamide 50 mg as combined therapy provides a survival advantage over castration alone. This treatment must be balanced against the potential for an increase in side-effects and a consequent adverse effect on the patient's quality of life.

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Citations

Jan 16, 2014·Cancer Metastasis Reviews·Michael A AugelloKaren E Knudsen
Sep 10, 2011·Endocrine-related Cancer·Matthew J SchiewerKaren E Knudsen
Jan 24, 2007·Current Urology Reports·Richard D SoweryMartin E Gleave
Jan 19, 2008·Expert Opinion on Pharmacotherapy·Eric A SingerEdward M Messing
Feb 9, 2010·Trends in Endocrinology and Metabolism : TEM·Karen E Knudsen, Trevor M Penning
May 16, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Jennifer A LockeEmma S Tomlinson Guns
Jul 26, 2011·Molecular and Cellular Endocrinology·Matthew J SchiewerKaren E Knudsen
Nov 13, 2008·Molecular and Cellular Endocrinology·Katherine L GrossJohn A Cidlowski
Feb 28, 2008·Nuclear Receptor Signaling·Steven P Balk, Karen E Knudsen

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