Combined antibacterial activity of amoxicillin with clavulanic acid against ampicillin-resistant strains.

Antimicrobial Agents and Chemotherapy
M MatsuuraS Mitsuhashi

Abstract

Strains of bacteria resistant to beta-lactam antibiotics have been increasing in number and are becoming troublesome in clinical medicine. The in vitro antibacterial activity of amoxicillin combined with clavulanic acid was determined on selected ampicillin-resistant clinical isolates. Synergistic effects were produced by amoxicillin with clavulanic acid against ampicillin-resistant strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, and Bacteroides fragilis. Inhibition of the beta-lactamases produced by the ampicillin-resistant strains was confirmed, especially against the penicillinases mediated by the R factor and the cephalosporinases produced by P.vulgaris and B. fragilis. The inhibitory effect of clavulanic acid against beta-lactamases was irreversible because of the high affinity of clavulanic acid to the enzymes.

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Citations

Jan 31, 2009·Nature Reviews. Drug Discovery·Jia JiaYu Zong Chen
Jul 23, 2014·BMC Pharmacology & Toxicology·Michiel HaesekerAnnelies Verbon
Aug 1, 1981·Antimicrobial Agents and Chemotherapy·K HiraiS Mitsuhashi
Aug 1, 1982·Antimicrobial Agents and Chemotherapy·F CrokaertE Yourassowsky
Sep 1, 1982·Antimicrobial Agents and Chemotherapy·D AdamP Koeppe
Oct 1, 1982·Antimicrobial Agents and Chemotherapy·A Iravani, G A Richard
Oct 2, 2020·Chemical Communications : Chem Comm·Arjaree JobdeedamrongDaniel Crespy
Mar 12, 2020·ACS Infectious Diseases·Declan Alan Gray, Michaela Wenzel

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