Combined antihypertensive therapy: vasodilatation using prazosin in combination with beta-adrenoceptor blockers and diuretics

Current Medical Research and Opinion
A Urban Waern

Abstract

An open study was carried out in 20 hypertensive patients, who had inadequate blood pressure control with beta-adrenoceptor blocking drugs and diuretics, to investigate the effects of adding prazosin to their existing treatment regimen. Patients received a mean daily dose of prazosin of 8.7 +/- 4.4 mg over a period of 12 weeks. The results showed that there was a significant reduction in systolic and diastolic blood pressures in the resting position. Only a few side-effects were reported and these occurred during the first 4 weeks whilst prazosin dosage was being adjusted. Weight increase, however, was noted in all but 4 of the patients. It is suggested that this may have been due partly to fluid retention, even though the majority were receiving diuretics, or possibly to changed carbohydrate-insulin metabolism.

Citations

Jun 1, 1976·Circulation·W J MroczekF A Finnerty
Mar 1, 1977·American Heart Journal·L Hansson, L Werkö
May 10, 1975·Lancet·R GabrielB C Ghosh
Aug 2, 1975·British Medical Journal·Y K SeedatJ G Rampono
Mar 23, 1972·The New England Journal of Medicine·R ZacestJ Koch-Weser
May 1, 1973·British Heart Journal·P A MajidS H Taylor
Jun 1, 1972·American Heart Journal·F J ZachariasB G Wall

Related Concepts

Urinary Retention
Polychemotherapy
Diuretic Effect
Hypertensive Disease
Quinazolines
Vascular Endothelium-Dependent Relaxation
Pratsiol
Pulse Rate
Adrenergic beta-Antagonists

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