Combined antihypertensive therapy: vasodilatation using prazosin in combination with beta-adrenoceptor blockers and diuretics

Current Medical Research and Opinion
A Urban Waern


An open study was carried out in 20 hypertensive patients, who had inadequate blood pressure control with beta-adrenoceptor blocking drugs and diuretics, to investigate the effects of adding prazosin to their existing treatment regimen. Patients received a mean daily dose of prazosin of 8.7 +/- 4.4 mg over a period of 12 weeks. The results showed that there was a significant reduction in systolic and diastolic blood pressures in the resting position. Only a few side-effects were reported and these occurred during the first 4 weeks whilst prazosin dosage was being adjusted. Weight increase, however, was noted in all but 4 of the patients. It is suggested that this may have been due partly to fluid retention, even though the majority were receiving diuretics, or possibly to changed carbohydrate-insulin metabolism.


Jun 1, 1976·Circulation·W J MroczekF A Finnerty
Mar 1, 1977·American Heart Journal·L Hansson, L Werkö
May 10, 1975·Lancet·R GabrielB C Ghosh
Aug 2, 1975·British Medical Journal·Y K SeedatJ G Rampono
Mar 23, 1972·The New England Journal of Medicine·R ZacestJ Koch-Weser
May 1, 1973·British Heart Journal·P A MajidS H Taylor
Jun 1, 1972·American Heart Journal·F J ZachariasB G Wall

Related Concepts

Urinary Retention
Diuretic Effect
Hypertensive Disease
Vascular Endothelium-Dependent Relaxation
Pulse Rate
Adrenergic beta-Antagonists

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Hormone and Metabolic Research. Supplement Series
K IrsiglerM Franetzki
Acta Bio-medica : Atenei Parmensis
Gaia ChiesaGiuseppe Chiumello
© 2020 Meta ULC. All rights reserved