Combined antioxidant therapy reduces pain and improves quality of life in chronic pancreatitis.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Gareth R KirkBrian J Rowlands

Abstract

Patients with chronic pancreatitis (CP) typically suffer intractable abdominal pain that is resistant to most analgesic strategies. Recent research indicates that the pain of CP may be in part due to oxygen free radical induced pancreatic damage. Using a randomized, double-blind, placebo-controlled crossover trial, we evaluated the efficacy of a combined antioxidant preparation in the management of CP. Patients with confirmed chronic pancreatitis (N = 36) were randomized to receive treatment with either Antox, which contains the antioxidants selenium, betacarotene, L-methionine, and vitamins C and E, or placebo for 10 weeks. Each group of patients then switched to receive the alternative treatment for a further 10 weeks. Markers of antioxidant status were measured by blood sampling, whereas quality of life and pain were assessed using the SF-36 questionnaire. Nineteen patients completed the full 20 weeks of treatment. Treatment with Antox was associated with significant improvements in quality of life in terms of pain (+17 antioxidant vs. -7 placebo), physical (+9 vs. -3) and social functioning (+8 vs. -7), and general health perception (+10 vs. -3). We conclude that treatment with antioxidants may improve quality of life and r...Continue Reading

References

Jul 1, 1979·The British Journal of Surgery·J E Trapnell
Jan 1, 1992·Free Radical Biology & Medicine·M H SchoenbergH G Beger
Jan 1, 1990·Free Radical Biology & Medicine·P M GuyanJ M Braganza
Aug 1, 1987·The British Journal of Surgery·A R Moossa
Jan 1, 1987·Pancreas·J M BraganzaR F McCloy
Jul 31, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·I SegalJ M Braganza
Sep 1, 1994·Occupational and Environmental Medicine·R McNameeN M Cherry
Apr 1, 1996·QJM : Monthly Journal of the Association of Physicians·J M Braganza
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·J H Sweiry, G E Mann
May 19, 2000·Annals of Surgery·J J HuangJ L Cameron
Apr 9, 2001·Pancreas·A Szuster-CiesielskaM Kandefer-Szerszeń
Jun 22, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H LegendreJ C Pector

❮ Previous
Next ❯

Citations

Oct 8, 2008·Antioxidants & Redox Signaling·Po Sing Leung, Yuk Cheung Chan
Jun 8, 2011·Antioxidants & Redox Signaling·Yuk Cheung Chan, Po Sing Leung
Sep 10, 2011·Antioxidants & Redox Signaling·Rakesh Kumar Tandon, Pramod Kumar Garg
Sep 25, 2009·World Journal of Gastroenterology : WJG·Seyed Sajad Mohseni Salehi MonfaredMohammad Abdollahi
Aug 24, 2010·World Journal of Gastroenterology : WJG·Nehal S ShahAjith K Siriwardena
Oct 24, 2013·World Journal of Gastroenterology : WJG·Rupjyoti Talukdar, D Nageshwar Reddy
Jan 31, 2016·Chemico-biological Interactions·Koukou LiJuanjuan Qu
Apr 9, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Chun-Hua ZhouShao-Feng Wang
May 4, 2013·Gastroenterología y hepatología·Enrique de-MadariaUNKNOWN Club Español Pancreático
Feb 22, 2012·Gastroenterology Clinics of North America·Guru TrikudanathanSanthi Swaroop Vege
Sep 17, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jan G D'HaeseHelmut Friess
Aug 30, 2011·Primary Care·John Affronti
Feb 1, 2011·Free Radical Biology & Medicine·Daniela SalveminiWilliam L Neumann
Feb 24, 2009·Gastroenterología y hepatología·Luisa GuarnerJorge Olsina
Mar 6, 2009·Trends in Pharmacological Sciences·Daniela Salvemini, William L Neumann
May 30, 2007·Gastroenterology Clinics of North America·Kenneth E FasanellaDavid C Whitcomb
Aug 26, 2009·Acta Anaesthesiologica Scandinavica·A Miclescu, T Gordh
Mar 17, 2009·Alimentary Pharmacology & Therapeutics·J G Lieb, C E Forsmark
Nov 19, 2010·Alimentary Pharmacology & Therapeutics·F BurtonUNKNOWN North American Pancreatic Study Group
May 15, 2013·Free Radical Research·P Bhardwaj, R K Yadav
Jul 19, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Dongkai ZhouShusen Zheng
Mar 9, 2007·Orvosi hetilap·Beatrix Sármán, Zsolt Tulassay
Feb 5, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Rupjyoti TalukdarD Nageshwar Reddy
Mar 15, 2011·Lancet·Joan M BraganzaMichael J McMahon
Mar 13, 2014·Wiener medizinische Wochenschrift·Hana NechutovaMiroslav Soucek
Jan 12, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Stephen A McClave
Jan 15, 2014·Scottish Medical Journal·P Paisley, J Kinsella
Apr 20, 2014·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Elham AfghaniVikesh K Singh
Aug 13, 2010·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Sinéad DugganKevin Conlon
Jul 8, 2011·Digestive Diseases·Claudia NitscheMarkus M Lerch
Feb 22, 2017·World Journal of Gastrointestinal Pharmacology and Therapeutics·Murli ManoharAnil Mishra
Aug 22, 2014·The Cochrane Database of Systematic Reviews·Usama Ahmed AliMarja A Boermeester
Jun 22, 2018·Journal of Pediatric Gastroenterology and Nutrition·Maisam Abu-El-HaijaVeronique D Morinville
Nov 14, 2018·Biomolecular Concepts·Troy L Merry, Maxim S Petrov
Sep 1, 2007·Current Opinion in Gastroenterology·Paul Georg Lankisch
Aug 2, 2007·Journal of Clinical Gastroenterology·George H SakorafasGeorge Peros
Dec 27, 2007·Yonsei Medical Journal·Xin-Liang LuKe-Da Qian
May 1, 2009·Nature Reviews. Gastroenterology & Hepatology·Jens Werner, Markus W Büchler
Jun 19, 2009·Current Opinion in Gastroenterology·Matthew J DiMagno, Eugene P DiMagno
Jun 15, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Maxim S Petrov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.