PMID: 11918543Mar 29, 2002Paper

Combined arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia recurring from previous relapses successfully treated using arsenic trioxide

British Journal of Haematology
W Y AuY L Kwong

Abstract

The optimal treatment of acute promyelocytic leukaemia (APL) recurring from relapses successfully treated using arsenic trioxide (As2O3) is undefined. Three APL patients relapsing from As2O3-induced remission were studied. Re-treatment with As2O3 failed in one patient in third relapse, and resulted in morphological but not molecular remission in another patient. Combination therapy with As2O3 and all-trans retinoic acid (ATRA), however, resulted in morphological and molecular remission in all three cases, with a follow-up time ranging from 6 to 16 months. Our results suggest a synergistic therapeutic effect between As2O3 and ATRA in APL in advanced relapse.

References

Nov 5, 1998·The New England Journal of Medicine·S L SoignetR P Warrell
Apr 6, 1999·The Journal of Experimental Medicine·V Lallemand-BreitenbachH de Thé
Oct 3, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W Y AuY L Kwong

❮ Previous
Next ❯

Citations

Jan 14, 2003·Hematological Oncology
Sep 6, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A PetitM Vasse
Feb 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jiong HuZhu Chen
Feb 27, 2008·Acta Pharmacologica Sinica·Wing-Yan Au, Yok-Lam Kwong
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zhi-Xiang ShenZhu Chen
May 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sabine KussJanine Mauzeroll
Jul 16, 2005·Hematology·Yair Gazitt, Cagla Akay
Dec 18, 2013·The Journal of Experimental Medicine·Guilherme Augusto Dos SantosPier Paolo Pandolfi
Oct 11, 2007·Leukemia & Lymphoma·Wing-Yan AuYok-Lam Kwong
Feb 9, 2012·Expert Opinion on Therapeutic Targets·Yok-Lam Kwong
Feb 5, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Kuan H LinJoen-Rong Sheu
Sep 8, 2011·Pediatric Blood & Cancer·Wing Y AuYok-lam Kwong
Jul 10, 2013·Respiratory Medicine·James Chung-Man HoMary Sau-Man Ip
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emmanuel RaffouxHervé Dombret
Jan 12, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xichuang ChenZhimin Du
Sep 5, 2002·Nature Reviews. Cancer·Jun ZhuHugues de Thé

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.