Combined assessment of polymorphisms in the LHCGR and FSHR genes predict chance of pregnancy after in vitro fertilization

Human Reproduction
I LindgrenY Lundberg Giwercman

Abstract

Can gonadotrophin receptor variants separately or in combination, be used for the prediction of pregnancy chances in in vitro fertilization (IVF) trials? The luteinizing hormone/human chorionic gonadotrophin receptor (LHCGR) variant N312S and the follicle-stimulating hormone receptor (FSHR) variant N680S can be utilized for the prediction of pregnancy chances in women undergoing IVF. The FSHR N680S polymorphism has been shown to affect the ovarian response in response to gonadotrophin treatment, while no information is currently available regarding variants of the LHCGR in this context. Cross-sectional study, duration from September 2010 to February 2015. Women undergoing IVF were consecutively enrolled and genetic variants compared between those who became pregnant and those who did not. The study was subsequently replicated in an independent sample. Granulosa cells from a subset of women were investigated regarding functionality of the genetic variants. Women undergoing IVF (n = 384) were enrolled in the study and genotyped. Clinical variables were retrieved from medical records. For replication, an additional group of n = 233 women was utilized. Granulosa cells from n = 135 women were isolated by flow cytometry, stimulated w...Continue Reading

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Citations

Jan 13, 2017·European Journal of Endocrinology·A Kirstine BangNiels Jørgensen
Mar 29, 2018·Reproductive Sciences·Kallirhoe KalinderiVangelis G Manolopoulos
Feb 9, 2018·Current Medical Research and Opinion·Ilaria Soave, Roberto Marci
Aug 29, 2018·Reproduction in Domestic Animals = Zuchthygiene·Dedi WangQifa Li
May 23, 2019·Journal of Assisted Reproduction and Genetics·Noa AbrahamiJohnny S Younis
May 23, 2019·Molecular Reproduction and Development·Sayyed Mohammad Hossein GhaderianSaghar Salehpour
Feb 8, 2019·Reproductive Biology and Endocrinology : RB&E·Alessandro ConfortiCarlo Alviggi
Nov 24, 2019·Journal of Assisted Reproduction and Genetics·Stine Aagaard LundingAnders Nyboe Andersen
Jul 19, 2019·Frontiers in Endocrinology·Alessandro ConfortiCarlo Alviggi
Mar 3, 2020·Hormone Molecular Biology and Clinical Investigation·Chrysa PaschalidouDimitrios Loutradis
Aug 28, 2020·Therapeutic Advances in Reproductive Health·Panagiotis DrakopoulosChristophe Blockeel
Sep 21, 2018·Journal of Assisted Reproduction and Genetics·I LindgrenY Lundberg Giwercman
May 26, 2021·Journal of Assisted Reproduction and Genetics·Xinrui WangXin Feng
May 30, 2021·Journal of Assisted Reproduction and Genetics·Sayyed Mohammad Hossein GhaderianSaghar Salehpour
Jul 16, 2021·Therapeutic Advances in Reproductive Health·Liese BoudryChristophe Blockeel
Aug 16, 2021·Reproductive Biomedicine Online·Chun GuoXiangqin Liu

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