PMID: 9420668Jan 1, 1994Paper

Combined assessment of regional perfusion and wall motion in patients with coronary artery disease with technetium 99m tetrofosmin

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
N TakahashiJ Konishi

Abstract

Technetium 99m tetrofosmin is a new 99mTc-labeled myocardial perfusion agent that can be labeled easily and provides excellent myocardial perfusion images. In addition, bolus administration of the tracer allows first-pass radionuclide ventriculography. This study examined the diagnostic value of combined assessment of regional perfusion by tetrofosmin tomography and wall motion by first-pass radionuclide ventriculography both at rest and during stress in 24 patients suspected of having coronary artery disease. All patients underwent stress-rest tetrofosmin tomography, stress-delayed thallium 201 tomography, and coronary angiography. Stress tetrofosmin tomography showed abnormal perfusion in all 23 patients with angiographic evidence of coronary artery disease, whereas stress 201Tl tomography showed abnormal perfusion in 22 of the 23 patients. For detection of significant (> or = 50% diameter stenosis) stenotic coronary arteries, the two perfusion studies showed similar sensitivities (62% with 201Tl and 69% with tetrofosmin) and specificities (88% and 100%, respectively). When analysis of regional wall motion was combined with perfusion study, a slightly higher sensitivity was obtained (77%), with similar specificity. The region...Continue Reading

References

Jul 11, 1988·The American Journal of Cardiology·J N Cohn, T S Rector
Jan 1, 1984·International Journal of Nuclear Medicine and Biology·A G JonesA I Kassis
Dec 1, 1982·Circulation·E Braunwald, R A Kloner

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Citations

Jul 1, 1996·European Journal of Nuclear Medicine·G Hör
May 1, 1997·Annals of Nuclear Medicine·N TamakiJ Konishi
Aug 9, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yen-Wen WuRuoh-Fang Yen
Jul 1, 1996·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R C HendelM C Gerson
Mar 21, 1998·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·P J HuangC T Su
Aug 26, 1998·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·J Y ChoiW R Lee
Nov 18, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Ichiro MatsunariNorihisa Tonami
Jun 4, 1999·Annals of Nuclear Medicine·H TakekawaY Kawakami
Apr 17, 2001·Cardiology in Review·P Kailasnath, A J Sinusas
Dec 29, 2000·Nuclear Medicine Communications·A TausigK Hahn

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