Combined association of recipient killer cell immunoglobulin-like haplotype AA and donor HLA-C*07 gene with BK virus associated nephropathy in kidney transplant patients

HLA : Immune Response Genetics
Ivana Kovacevic VojtusekRenata Zunec

Abstract

Kidney transplant recipient killer cell immunoglobulin-like receptors (KIR) genotype and HLA-C status of their donors have been separately associated with BK virus-associated nephropathy (BKVAN) and BK virus infection. Our aim was to determine whether different combinations of recipients KIR genes and donor HLA-C ligands influence the risk of BKVAN. Retrospective case-control study included 23 recipients with BKVAN and 46 recipients with persistently negative BK virus. Donor HLA-C*07 positivity was associated with lower odds for BKVAN, recipients bearing KIR haplotype AA or lacking any activating KIR genes were more frequent in BKVAN while recipient/donor combination HLA-C*07 negative/KIR AA positive was significantly associated with BKVAN. Our study complements and confirms results from several previously published studies, suggesting potential clinical usefulness.

References

Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Daniel L BohlDaniel C Brennan
May 1, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M SternC Hess
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H H HirschUNKNOWN AST Infectious Diseases Community of Practice
Oct 28, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Etienne BrochotNicolas Guillaume

❮ Previous
Next ❯

Citations

Feb 6, 2021·Pathogens·Yasuhito Funahashi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.

Related Papers

Transplant International : Official Journal of the European Society for Organ Transplantation
Etienne BrochotNicolas Guillaume
International Journal of Organ Transplantation Medicine
B Einollahi, I Lotfian
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Xiaoyou LiuShaojie Fu
© 2021 Meta ULC. All rights reserved