Combined behavioral and individualized drug therapy versus individualized drug therapy alone for urge urinary incontinence in women

The Journal of Urology
Kathryn L BurgioDavid T Redden

Abstract

We tested whether individualized drug therapy enhanced with behavioral training would result in better outcomes than individualized drug therapy alone. Participants were community dwelling women with urge predominant incontinence. Using a randomized clinical trial design women were randomized to 8 weeks (4 visits) of drug therapy alone (32) or drug therapy plus behavioral training (32). Drug therapy was individually titrated, extended release oxybutynin with proactive management of side effects. Behavioral training included pelvic floor muscle training and urge suppression techniques. The primary outcome measure was reduction in frequency of incontinence episodes on bladder diary at 8 weeks (with followup at 6 and 12 months). Secondary outcomes included patient satisfaction, global perception of improvement, Urogenital Distress Inventory and Incontinence Impact Questionnaire. In intent to treat analysis frequency of incontinence was reduced a mean of 88.5% in the drug alone group and 78.3% in the combined therapy group (p = 0.16). Outcomes were not significantly different between the groups in the analysis of completers (91.5% vs 86.2%, p = 0.34), or in either analysis at 6 or 12 months. The groups also did not differ significa...Continue Reading

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Citations

Jan 21, 2016·Lower Urinary Tract Symptoms·Satoru TakahashiMasayasu Koyama
Dec 4, 2013·The Nursing Clinics of North America·Stephen D Krau
May 14, 2016·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Jose Carlos TruzziRicardo Reges
Nov 4, 2015·The Cochrane Database of Systematic Reviews·Reuben Olugbenga AyelekeMuhammad Imran Omar
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Bhavan Prasad RaiLaurence Stewart

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