Combined beneficial effect of rasagiline on motor function and depression in de novo PD

Clinical Neuropharmacology
Alexei KorchounovWolfgang Rössy

Abstract

To investigate prokinetic and antidepressive effects of rasagiline in de novo Parkinson disease (PD). Patients with newly diagnosed PD with comorbid untreated depression were randomly assigned to rasagiline monotherapy 1 or 2 mg/d. Unified Parkinson's Disease Rating Scale Part 2 (Activity of Daily Living) and Part 3 (Motor Function), and Hamilton Depression Rating Scale (HDRS) assessments were carried out by a blinded investigator in each patient at baseline and after 8 weeks of rasagiline treatment. Both groups showed equal motor improvement at the end point. The improvements of HDRS score and activity of daily living were significantly more pronounced with rasagiline, 2 mg/d, than rasagiline, 1 mg/d (P = 0.0002). The treatment with rasagiline, 2 mg/d, improved symptoms in all HDRS core depression symptoms and specifically those not considered to be influenced by motor function: mood, guilt, psychic anxiety, and hypochondria. Our results suggest that antidepressive effect seen in higher dosage of rasagiline may be not related to the motor improvement.

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Citations

Jun 6, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sara Mínguez-MínguezJoaquín Jordán
May 3, 2013·Expert Opinion on Drug Safety·Julián Solís-García del PozoJoaquín Jordán
Mar 24, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·E PeñaUNKNOWN en nombre del grupo de trastornos del movimiento de la Asociación Madrileña de Neurología
Apr 16, 2015·Frontiers in Neurology·Maritza Sandoval-RincónOscar Arias-Carrión
Aug 15, 2014·Frontiers in Aging Neuroscience·Rakhee KrishnaAhmed A Moustafa
Nov 3, 2016·Frontiers in Pharmacology·John P M Finberg, Jose M Rabey
Jun 24, 2017·CNS Drugs·Eva Schaeffer, Daniela Berg
Jan 18, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Klaus SeppiUNKNOWN the collaborators of the Parkinson's Disease Update on Non-Motor Symptoms Study Group on behalf of the Movement Disorders So
May 24, 2019·Expert Opinion on Pharmacotherapy·Melody RyanJohn T Slevin
Mar 24, 2018·Journal of Neural Transmission·Peter Riederer, Thomas Müller
Apr 5, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Anna CastriotoPaul Krack
Nov 2, 2019·Journal of Nutritional Science and Vitaminology·Yasuhisa AnoKeiji Kondo
May 28, 2019·Journal of the Neurological Sciences·Alberto J EspayUNKNOWN Parkinson's Progression Markers Initiative

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