Combined benzoporphyrin derivative monoacid ring photodynamic therapy and pulsed dye laser for port wine stain birthmarks.

Photodiagnosis and Photodynamic Therapy
Joshua A TournasKristen M Kelly

Abstract

Pulsed dye laser (PDL) is a commonly utilized treatment for port wine stain birthmarks (PWS) in the United States; however, results are variable and few patients achieve complete removal. Photodynamic therapy (PDT) is commonly used in China, but treatment associated photosensitivity lasts several weeks and scarring may occur. We propose an alternative treatment option, combined PDT+PDL and performed a proof-of-concept preliminary clinical trial. Subjects with non-facial PWS were studied. Each subject had four test sites: control, PDL alone, PDT alone (benzoporphyrin derivative monoacid ring A photosensitizer with 576 nm light), and PDT+PDL. Radiant exposure time for PDT was increased in increments of 15 J/cm(2). Authors evaluated photographs and chromametric measurements before and 12 weeks post-treatment. No serious adverse events were reported; epidermal changes were mild and self-limited. No clinical blanching was noted in control or PDT-alone sites. At PDT radiant exposures of 15 and 30 J/cm(2), equivalent purpura and blanching was observed at PDL and PDT+PDL sites. At PDT radiant exposures over 30 J/cm(2), greater purpura was noted at PDT+PDL sites as compared to PDL alone. Starting at 75 J/cm(2), improved blanching was no...Continue Reading

References

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Citations

Jun 3, 2011·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·E SattlerC Kunte
Mar 11, 2011·Lasers in Medical Science·Annette KleinPhilipp Babilas
Jul 17, 2013·Actas dermo-sifiliográficas·R de MiguelP Boixeda
Mar 8, 2013·Annales de dermatologie et de vénéréologie·C Lavogiez-DermauxS Mordon
May 30, 2012·Seminars in Cutaneous Medicine and Surgery·Amit M PatelKristen M Kelly
Dec 4, 2012·Photodiagnosis and Photodynamic Therapy·Kai-Hua YuanZheng Huang
Feb 7, 2012·Journal of the American Academy of Dermatology·Jennifer K ChenMichal Heger
Jul 19, 2014·The Journal of Investigative Dermatology·Kristen M KellyBernard Choi
Feb 16, 2012·Lasers in Surgery and Medicine·Wesley J MoyBernard Choi
Mar 26, 2016·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Bernard ChoiJ Stuart Nelson
Feb 1, 2018·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·M Ingmar van RaathMichal Heger
Nov 27, 2019·Photochemistry and Photobiology·Daniel KrausBin Chen
Aug 23, 2020·Cancers·Taketo SuzukiHiromi Kataoka
Dec 29, 2020·Pediatric Dermatology·Jennifer M TranLisa M Arkin

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