Combined blockade of angiotensin II type 1 receptor and activation of peroxisome proliferator-activated receptor-γ by telmisartan effectively inhibits vascularization and growth of murine endometriosis-like lesions

Human Reproduction
A NenicuM W Laschke

Abstract

Is telmisartan effective in the treatment of endometriosis? Combined blockade of angiotensin II type 1 receptor (AT1R) and activation of peroxisome proliferator-activated receptor (PPAR)-γ by telmisartan inhibits vascularization and growth of murine endometriosis-like lesions. AT1R and PPAR-γ are involved in the regulation of inflammation, proliferation and angiogenesis. These processes are also crucial for the pathogenesis of endometriosis and both receptors are expressed in endometrial tissue. Telmisartan is a partial agonist of PPAR-γ, which additionally blocks AT1R. This was a randomized study in the mouse dorsal skinfold chamber and peritoneal model of endometriosis. Endometriosis-like lesions were induced in dorsal skinfold chambers of 21 female C57BL/6 mice, and in the peritoneal cavity of 15 additional animals, which were daily treated with an i.p. injection of pioglitazone (10 mg/kg, n = 12), telmisartan (10 mg/kg, n = 12) or vehicle (5% dimethyl sulfoxide (DMSO), n = 12) throughout an observation period of 14 and 28 days, respectively. The anti-angiogenic actions of pioglitazone, a full PPAR-γ agonist, and telmisartan were firstly assessed in vitro by an aortic ring assay. Endometriosis-like lesions were induced in th...Continue Reading

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Citations

Apr 10, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Panayiota PloutarchouSuzannah A Williams
Oct 11, 2014·The Journal of Obstetrics and Gynaecology Research·Bulent CakmakOytun Erbaş
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Feb 13, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Tingting LiaoZhangye Xu
Dec 24, 2020·Human Reproduction·Nuria PellicerAntonio Pellicer
Jun 19, 2016·The American Journal of Pathology·Jeannette Rudzitis-AuthMatthias W Laschke
May 20, 2021·Minerva Obstetrics and Gynecology·Simona MartoneStefano Luisi
Jul 3, 2021·Pharmaceuticals·Alexandre ValléeYves Lecarpentier

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