Combined buccal and lingual mucosa grafts for urethroplasty: an experimental study in dogs
Abstract
To evaluate combined buccal mucosa and lingual mucosa grafts for urethroplasty in a dog model. Seven female mongrel dogs were randomly selected. After a segment of proximal urethra mucosa (4 cm × 1cm) was excised and onlayed urethroplasty was performed using the combined free buccal mucosa (2 cm × 1cm) graft harvested from the inferior cheek and free lingual mucosa graft (2 cm × 1cm) harvested from the inferior lateral surface of the tongue. A 12F urethral catheter was kept inside the urethra for a mean of 7 d. Retrograde urethrography was done and urethra diameter was calibrated with a 10Fr catheter before animals were sacrificed at wk 12. After sacrifice of all dogs, the grafted areas excised and evaluated by gross and histopathological examination. All dogs survived the procedure and there were no tongue and oral complications. One of the seven dogs developed a severe urethral stricture near the proximal anastomosis. The remaining six dogs voided spontaneously with no difficulty. Retrograde urethrography showed that no strictures or fistulas had formed. The combined buccal mucosa graft and lingual mucosa graft shortened by 10.2% after surgery, from a mean (SD) of 4 (0.15) to 3.59 (0.23) cm (statistical significance, P < 0.05...Continue Reading
References
Citations
Related Concepts
Related Feeds
Bladder Carcinoma In Situ
Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.