PMID: 7014043Jan 1, 1981Paper

Combined captopril and spironolactone treatment in Conn's syndrome with renal impairment and refractory hypertension

Clinical Endocrinology
A B AtkinsonJ I Robertson

Abstract

Spironolactone alone in full dosage failed to correct hypertension in a patient with Conn's syndrome and renal impairment, although the previously increased total exchangeable sodium fell to normal and the previously suppressed plasma angiotensin II did not rise above the normal range. Addition of the converting enzyme inhibitor captopril reduced plasma angiotensin II to very low levels, with a slight further fall in exchangeable sodium. Blood pressure was well controlled. Because hypertension in Conn's syndrome resistant to spironolactone usually also responds poorly to removal of the adenoma, and is difficult to treat with conventional hypotensive agents, the combination of a converting enzyme inhibitor with a potassium conserving diuretic is worthy of trial in such cases.

Citations

Jul 11, 2006·Der Internist·M Quinkler, M Reincke
Nov 1, 1985·Clinics in Endocrinology and Metabolism·J C Melby
Mar 24, 2006·Expert Opinion on Pharmacotherapy·Salim Janmohamed, Pierre-Marc G Bouloux
Apr 6, 2001·Journal of Hypertension·P O LimT M MacDonald
Aug 6, 2010·The Cochrane Database of Systematic Reviews·Josh BatterinkCurt T Fowkes
Nov 1, 1984·Kidney International·J C Melby

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