Combined chemotherapy and radiation in locally advanced non-small-cell lung cancer

The Lancet Oncology
Jacek Jassem

Abstract

The efficacy of radiotherapy in locally advanced non-small-cell lung cancer is limited. One attempt to improve survival uses a combination of radiation and chemotherapy. These two modalities can be applied in sequence or concurrently, but results from phase III trials of combined therapy versus radiation alone have been inconsistent. Early studies were mostly negative, but more recent trials using platinum-based regimens have shown some survival benefit for combined treatments. The positive impact of chemotherapy has also been shown in a meta-analysis. In recent studies, concurrent chemotherapy and radiation appears better than sequential application. However, the benefit of the combined approach is modest and should be balanced against increased early and late toxicity. The role of new agents such as taxanes, vinorelbine, gemcitabine, and topoisomerase inhibitors in combined modality therapy of non-small-cell lung cancer warrants further clinical investigation.

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Citations

Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J Jassem
Dec 7, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Matjaz Zwitter
Dec 7, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jacek Jassem
Feb 22, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jana Van ThielenPaul Van Schil
Sep 21, 2013·Lung India : Official Organ of Indian Chest Society·Manpreet Singh TiwanaDushyant Gaur
May 8, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jacek Jassem
Sep 2, 2015·Molecular Pharmaceutics·Imalka MunaweeraKenneth J Balkus
Nov 27, 2008·Journal of Experimental & Clinical Cancer Research : CR·Masao FujiwaraYasuyuki Suzuki
Apr 5, 2014·PLoS Computational Biology·Gerard J P van WestenJohn P Overington
Aug 5, 2009·Journal of the American College of Surgeons·Susan C PittMuthusamy Kunnimalaiyaan
Mar 22, 2003·Expert Review of Anticancer Therapy·Jacek Jassem
Jul 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth KentDavid C Smith

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