Combined chemotherapy and radiotherapy during conception and first two trimesters of gestation in a woman with metastatic breast cancer

Gynecologic Oncology
Charalampos AndreadisDespina Mouratidou

Abstract

A 33-year-old woman with T(4c)N(3) breast cancer with metastases in the skeleton (M(1)) received five cycles of 5-fluorouracil, epirubicin, and cyclophosphamide (FEC regimen) before conception and during the first trimester. Salvage radiotherapy (28 Gy) was delivered during the 17th week. Tamoxifen and zolendronic acid were also administered throughout the second and third trimesters. The patient was not aware of her pregnancy until the 28th week. A female phenotypically normal infant was delivered in the 35th week of gestation by cesarean section. The child is functioning normally 12 months after delivery. The literature of anthracycline treatment during conception and the first trimester is reviewed. The effects of tamoxifen and biphosphonate therapy on the fetus during pregnancy are also discussed.

References

Dec 1, 1976·Teratology·R W Miller, J J Mulvihill
Jan 1, 1990·Journal of Perinatal Medicine·H H KanhaiJ B Gravenhorst
Feb 1, 1990·Gynecologic Oncology·P H WillemseD T Sleijfer
Jan 15, 1966·British Medical Journal·T E BlecherK R Peel
Nov 9, 1984·JAMA : the Journal of the American Medical Association·C L MurrayL B Twiggs
Apr 1, 1981·Annals of Internal Medicine·V GarciaA L Borrasca
Jun 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·V Kafantaris
Apr 1, 1994·Critical Reviews in Oncology/hematology·V J Wiebe, P E Sipila
Jun 22, 1994·JAMA : the Journal of the American Medical Association·S L CullinsC M Sutherland
Aug 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·T MüllerT Steck
Jan 1, 1996·Clinical Oncology : a Journal of the Royal College of Radiologists·T M IllidgeC W Godden
Jul 19, 1997·Lancet·K TewariA M Shanberg
Jul 1, 1997·Clinical Therapeutics·K NakagawaY Sasaki
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D L BerryG N Hortobagyi
Dec 18, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N GermannF Goldwasser
May 4, 2004·The Lancet Oncology·Elyce Cardonick, Audrey Iacobucci
Apr 1, 1997·Expert Opinion on Investigational Drugs·S Crow
Mar 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Luciano MerliniPaolo Bernardi

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Citations

Sep 4, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O MirJ M Treluyer
Oct 7, 2011·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·R KeriakosS Buckley
Mar 4, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Emilia ParodiPiero Sismondi
Apr 16, 2013·Revista da Associação Médica Brasileira·Denise Leite Maia MonteiroBarbara Caldas
May 15, 2007·The Surgical Clinics of North America·Dawn M Barnes, Lisa A Newman
Feb 2, 2019·Breast Cancer Research and Treatment·T N SchuurmanC A R Lok
Nov 19, 2014·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Sarah B Green, Ashley L Pappas
Nov 27, 2008·The Journal of Clinical Endocrinology and Metabolism·Laura K Bachrach, Leanne M Ward
Sep 21, 2019·Hormone Molecular Biology and Clinical Investigation·Nikolaos MachairiotisLina Michala
Apr 27, 2021·The Breast : Official Journal of the European Society of Mastology·Cynthia MaxwellIrena Nulman
May 14, 2020·Breast Care·Barbara BuonomoFedro Alessandro Peccatori

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