PMID: 3623348Aug 1, 1987Paper

Combined chronic toxicity and carcinogenicity studies of morpholine oleic acid salt in B6C3F1 mice

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M ShibataN Ito

Abstract

Morpholine oleic acid salt (MOAS) was administered to groups of 50 male and 50 female B6C3F1 mice in the drinking-water at levels of 0, 0.25 and 1.0%. Both sexes given 1.0% MOAS and females given 0.25% showed growth retardation. Significant increases in blood-urea nitrogen concentrations were only observed in the 1.0% male group. The incidence of squamous-cell hyperplasia of the forestomach epithelium was significantly higher in the males given 1.0% than in the controls. The male mice given 0.25% MOAS had a significantly reduced incidence of hepatocellular carcinoma in comparison with the control group and this trend was indicated also in the 1.0% group. This experiment did not demonstrate any carcinogenic effect of MOAS in mice at levels up to 1.0% in the drinking-water.

References

Mar 1, 1975·Toxicology and Applied Pharmacology·S S Mirvish
Oct 1, 1984·Nihon eiseigaku zasshi. Japanese journal of hygiene·T Ohnishi
Oct 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A HagiwaraN Ito
Jul 1, 1982·Toxicology and Applied Pharmacology·O S SohnJ H Weisburger

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Citations

Feb 7, 1998·Reproductive Toxicology·P A FailJ J Heindel
Jan 11, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A Wallace Hayes
Jan 17, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Pei CaoHai-Bin Xu
Aug 1, 1990·Journal of Toxicology and Environmental Health·W C LauerJ F Borzelleca
Oct 31, 2000·Veterinary Pathology·J E Markovits, P S Sahota
Nov 28, 2006·Natural Product Research·Gagan KukrejaSurinder K Grover

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