Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix

The American Journal of Surgical Pathology
Runjan ChettyJorge Albores-Saavedra

Abstract

Carcinoid tumors are the most common neoplasms of the appendix. Histologically they have been categorized as classical, tubular, or goblet cell types. Goblet cell carcinoid has been regarded as a distinctive tumor type, not related to classic carcinoids, and to our knowledge combinations of these 2 tumor types have not been described in detail. In this report, we describe 5 cases of combined classical carcinoid and goblet cell carcinoid (GCC) tumors of the appendix. Four men and 1 woman, (mean age 53.4 y) presented with acute appendicitis (4 cases), whereas 1 presented with a pelvic mass owing to widespread pelvic disseminated disease. The tumors (0.6 to 6.0 cm) were located in the mid-portion and the tip of the appendix. Four patients were treated with right hemicolectomies (the patient with disseminated pelvic and ovarian metastases also had a pelvic exenteration), and 1 was treated with an appendectomy only. Four patients are alive and asymptomatic, whereas the patient with disseminated pelvic disease died 6 months after surgery. All 5 appendiceal tumors had microscopic features of both classical carcinoid and GCC, either intimately admixed or separate but closely apposed. The extent of the 2 components varied, with classica...Continue Reading

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Citations

Feb 24, 2010·World Journal of Surgical Oncology·Yi-Ping ZouNing Li
Oct 21, 2015·Endocrine-related Cancer·Krystallenia I AlexandrakiAshley B Grossman
Jun 27, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A D MalkanJ A Sandoval
Mar 31, 2015·Journal of Pathology and Translational Medicine·Su-Jin ShinKyu-Rae Kim
Jan 1, 2012·Gynecologic Oncology Case Reports·Alberto A MendivilBram H Goldstein
Jul 1, 2017·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jirka MacakJana Dvorackova
Apr 27, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M I Prieto-NietoG Domínguez
Oct 11, 2020·Molecular Cancer Therapeutics·Hiroyuki AraiHeinz-Josef Lenz

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