PMID: 11336760May 5, 2001Paper

Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy

Obstetrics and Gynecology
M J McMahon, A H James

Abstract

Combined deficiency of vitamin K-dependent coagulation factors (II, VII, IX, X) is an uncommon challenge for the expectant gravida. A 34-year-old primigravida had congenital combined deficiency of factors II, VII, IX, and X that were incompletely sensitive to vitamin K. She had an altered form of vitamin K-dependent factors that retained immunologic activity but lacked coagulant activity and the normal complement of gamma-carboxyglutamic acid residues. She required vitamin K supplementation throughout her life. After an uneventful pregnancy she had postpartum hemorrhage resulting from an episiotomy. Fresh frozen plasma was administered to achieve hemostasis. The remainder of her postpartum course was normal. Combined congenital deficiency of factors II, VII, IX, and X can be managed in pregnancy with the use of vitamin K and fresh frozen plasma.

References

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Citations

Nov 22, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Claudia Chi, Rezan A Kadir
Jan 26, 2010·Best Practice & Research. Clinical Obstetrics & Gynaecology·Patrick Thornton, Joanne Douglas
Aug 12, 2009·Clinics in Laboratory Medicine·Valerie L Ng
Sep 11, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·P H B Bolton-MaggsA D Mumford
Sep 11, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·C RomagnoloA Girolami
Mar 21, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·R KadirP Bolton-Maggs
Jan 15, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·B W Weston, P E Monahan
Dec 18, 2002·Journal of Midwifery & Women's Health·Wendy F HansenJerome Yankowitz
Dec 19, 2018·Blood·Marzia Menegatti, Flora Peyvandi
May 28, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·P TeixeiraR Kalil
Jul 16, 2020·Expert Review of Hematology·Akbar DorgalalehMahmood Shams

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