Combined Diagnostic Efficacy of Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Mean Platelet Volume (MPV) as Biomarkers of Systemic Inflammation in the Diagnosis of Colorectal Cancer

Disease Markers
Milica Stojkovic LalosevicZoran Krivokapic

Abstract

Systemic inflammation in colorectal cancer (CRC) may be reflected by neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV). This study was designed to investigate the efficiency of preoperative NLR, PLR, and MVP as a tool for the assessment of tumor characteristics in newly diagnosed patients with CRC. For 300 patients and 300 healthy volunteers, complete blood counts with automated differential counts were performed. The NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count; PLR was calculated by dividing the absolute platelet count by the absolute lymphocyte count. The diagnostic performance of NLR, PLR, and MVP was estimated by ROC curve. ROC curve analysis showed high diagnostic efficacy of NLR and PLR in CRC patients with cut-off values of 2.15 (AUC = 0.790, 95% CI 0.736-0.884, Se = 74.1%, and Sp = 73%) and 123 (AUC = 0.846, 95% CI 0.801-0.891, Se = 73.5%, and Sp = 80%) compared to healthy controls, respectively. The diagnostic efficacy of three combined markers was superior compared with individual markers (AUC = 0.904, 95% CI 0.812-0.989, Se = 96%, and Sp = 70%). NRL, PLR, and MPV may be useful markers in diagnostic and early recog...Continue Reading

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Citations

Feb 7, 2020·Cancer Medicine·Jungang LiuWeizhong Tang
Sep 10, 2019·World Journal of Gastroenterology : WJG·Anne E TuomistoJuha P Väyrynen
Aug 2, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yi FangHaitao Wu
Nov 3, 2020·Disease Markers·Angelika CopijaKatarzyna Walkiewicz
Nov 17, 2020·Journal of Community Hospital Internal Medicine Perspectives·Muhammad Sohaib AsgharSyeda Batool Tirmizi
Oct 30, 2020·Journal of Inflammation Research·Qian HuangRui Zhu
Aug 6, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Sirin Kucuk, Soycan Mızrak
Dec 4, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Matteo WinkerJörg Faber
Jan 11, 2022·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hayri BostanErman Cakal

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