Combined diagnostic imaging with 131I-metaiodobenzylguanidine and 111In-pentetreotide in carcinoid tumours

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Babs G TaalH Boot

Abstract

Carcinoid tumours derived from the neural crest are usually associated with the symptoms of flushing and diarrhoea in the presence of liver metastases. Scintigraphs with 131I-metaiodobenzylguanidine (131I-MIBG) which is accumulated in the argentaffin granules of the cell, as well as with 111In-pentetreotide for the imaging of somatostatin receptors on the cell surface, are positive in a large proportion of carcinoid patients. To evaluate the complementary role of both radionuclide tests, we studied 20 consecutive carcinoid patients: 14 with the characteristic carcinoid syndrome and 6 with tumour symptoms, such as pain or obstruction. A positive test was found in 84% with either 131I-MIBG or 111In-pentetreotide; the combination yielded a sensitivity of 95%. A positive correlation was found with the presence of the carcinoid syndrome, but not with 5-HIAA excretion. A positive test may help in adjusting treatment: either to predict the response to octreotide or to select patients for 131I-labelled MIBG treatment. Application of a therapeutic dose of 111In-pentetreotide may be limited by the high normal uptake in the kidneys.

References

Jan 1, 1987·European Journal of Nuclear Medicine·C A HoefnagelE E Engelsman
Mar 1, 1986·Clinical Nuclear Medicine·C A HoefnagelB G Taal
Jan 1, 1993·Acta Oncologica·O NilssonH Ahlman
Apr 1, 1993·European Journal of Nuclear Medicine·D J KwekkeboomS W Lamberts

❮ Previous
Next ❯

Citations

Jul 21, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Emilio BombardieriUNKNOWN European Association for Nuclear Medicine
Feb 11, 2005·Current Gastroenterology Reports·Babs G Taal
Mar 29, 2001·European Journal of Radiology·J RickeB Wiedenmann
Aug 7, 1999·The New England Journal of Medicine·I P KemaE G De Vries
Aug 19, 2006·Journal of Clinical Gastroenterology·Irvin M ModlinAnthony K C Chan
Sep 9, 2011·Journal of Pediatric Hematology/oncology·Raj P WarrierRandal Craver
Aug 27, 2002·Journal of Clinical Pathology·S Van EedenM-L F Van Velthuysen
Aug 2, 2011·Journal of Medical Case Reports·Silvia MeziFilippo La Torre
Dec 19, 2008·The Oncologist·Scott N PinchotHerbert Chen
Feb 26, 2011·Endocrinology and Metabolism Clinics of North America·David L Bushnell, Richard P Baum
Aug 3, 2006·Surgical Oncology Clinics of North America·Rebecca S Sippel, Herbert Chen
Jul 4, 2006·Gastrointestinal Endoscopy·Sebastiaan A C van TuylBabs G Taal
Nov 3, 2010·Journal of the American College of Surgeons·Anthony J ChambersOtto Rorstad
Jun 12, 2013·Expert Opinion on Pharmacotherapy·Nina Nandy, Constantin A Dasanu
May 25, 2002·Cancer Treatment Reviews·H de VriesE G E de Vries
Jan 27, 2009·Technology in Cancer Research & Treatment·Ian M BesseMalik E Juweid
Feb 16, 2017·AJR. American Journal of Roentgenology·Andrew J DegnanShannon Tocchio
Jun 10, 2006·Seminars in Nuclear Medicine·Vittoria RufiniRichard P Baum
Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·W W de Herder
Jul 27, 2018·The British Journal of Radiology·Archi AgrawalNilendu Purandare
Oct 26, 2011·Endocrine-related Cancer·Jaap J M TeunissenEric P Krenning
Feb 15, 2005·The Oncologist·Johanna M Zuetenhorst, Babs G Taal
Nov 1, 2002·Scandinavian Journal of Gastroenterology. Supplement·P F H J QuaedvliegB G Taal
Jan 6, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B G TaalM Rutgers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.