Combined Dietary Anthocyanins, Flavonols, and Stilbenoids Alleviate Inflammatory Bowel Disease Symptoms in Mice

Frontiers in Nutrition
Aurelia ScaranoAngelo Santino

Abstract

Dietary polyphenols are associated with a wide range of health benefits, protecting against chronic diseases and promoting healthy aging. Dietary polyphenols offer a complementary approach to the treatment of inflammatory bowel diseases (IBDs), a group of common chronic intestinal inflammation syndromes for which there is no cure. Tomato is widely consumed but its content of polyphenols is low. We developed a tomato variety, Bronze, enriched in three distinct classes of polyphenols: flavonols, anthocyanins, and stilbenoids. Using Bronze tomatoes as a dietary supplement as well as Indigo (high anthocyanins and flavonols), ResTom (high stilbenoids) and wild-type tomatoes, we examined the effects of the different polyphenols on the host gut microbiota, inflammatory responses, and the symptoms of chronic IBD, in a mouse model. Bronze tomatoes significantly impacted the symptoms of IBD. A similar result was observed using diets supplemented with red grape skin containing flavonols, anthocyanins, and stilbenoids, suggesting that effective protection is provided by different classes of polyphenols acting synergistically.

References

Dec 16, 2006·Plant Biotechnology Journal·Giovanna GiovinazzoLaura DeGara
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Jun 19, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akira AndohYoshihide Fujiyama
Jul 2, 2009·Nutrition Reviews·Béatrice RomierAlexandrine During
Oct 20, 2009·International Journal of Food Microbiology·Deisy Hervert-HernándezIsabel Goñi
Feb 6, 2010·European Journal of Pharmacology·Susana Sánchez-FidalgoCatalina Alarcón de la Lastra
May 19, 2011·The Plant Cell·Cathie MartinChiara Tonelli
May 4, 2012·The American Journal of Clinical Nutrition·María Isabel Queipo-OrtuñoFrancisco J Tinahones
Jun 6, 2012·Journal of Biomedicine & Biotechnology·Martina Perše, Anton Cerar
Feb 8, 2013·Current Gastroenterology Reports·Sunny H Wong, Siew C Ng
Jun 29, 2013·Journal of Food Science·Rui Hai Liu
Nov 28, 2013·Journal of Agricultural and Food Chemistry·Jose L AleixandreRafael Aleixandre-Benavent
Mar 7, 2014·Frontiers in Immunology·Berit Carow, Martin E Rottenberg
Jan 27, 2015·Critical Reviews in Food Science and Nutrition·Shama V JosephBritt M Burton-Freeman
Mar 4, 2015·Nature Reviews. Gastroenterology & Hepatology·Ashwin N Ananthakrishnan
Jun 19, 2015·Frontiers in Immunology·Kai FangChristopher G Kevil
Jun 23, 2015·European Journal of Immunology·Francesca Romana DelvecchioMarcello Chieppa
Sep 5, 2015·Gut·Julian R MarchesiAilsa Hart
Oct 27, 2015·Nature Communications·Yang ZhangCathie Martin
Dec 24, 2015·Frontiers in Immunology·Stefania De SantisMarcello Chieppa
Sep 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nadia CalabrisoMaria Annunziata Carluccio
Jan 13, 2017·Current Pharmaceutical Design·Vanessa GalleggianteMarcello Chieppa
Feb 22, 2017·Current Pharmaceutical Design·Marcello ChieppaAngelo Santino
Sep 16, 2017·Journal of Food and Drug Analysis·Makoto Shimizu

❮ Previous
Next ❯

Citations

Aug 24, 2018·Expert Review of Gastroenterology & Hepatology·Mohammad Hosein FarzaeiNima Rezaei
Jun 30, 2019·Plant Biotechnology Journal·Shiyu YingYang Zhang
Jul 11, 2019·Planta·Antonella SuccurroTimothy O Jobe
Feb 6, 2020·Journal of the Science of Food and Agriculture·Aurelia ScaranoMaria Manuela Rigano
May 4, 2018·Frontiers in Medicine·Marcello Chieppa, Gianluigi Giannelli
Feb 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jose D JaimesJaroslav Havlik
Sep 27, 2019·Frontiers in Nutrition·Federica BlandoØyvind M Andersen
Jan 1, 2019·Critical Reviews in Food Science and Nutrition·Lingmin TianWeibin Bai
Feb 4, 2021·Nutrients·Giulio VernaPietro Campiglia
Jan 21, 2021·Cancers·Stefania De SantisMarcello Chieppa
Oct 24, 2020·Antioxidants·Silvia Gonzali, Pierdomenico Perata
Mar 7, 2021·Nutrients·Hira ShakoorLily Stojanovska
Apr 4, 2021·International Journal of Molecular Sciences·Raffaella BalestriniElisa Zampieri
Oct 23, 2020·Chemical Reviews·Christopher P HopperBinghe Wang
Jun 29, 2021·Frontiers in Cellular and Infection Microbiology·Stefania De SantisMarcello Chieppa
Aug 8, 2021·International Journal of Molecular Sciences·Giulio VernaMarcello Chieppa
Jul 7, 2020·Anti-cancer Agents in Medicinal Chemistry·Palmiro PoltronieriGiovanna Giovinazzo

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

Genomix4life

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.