PMID: 8960111Oct 1, 1996Paper

Combined differentiating therapy for myelodysplastic syndromes: a phase II study

Leukemia Research
Dario FerreroA Pileri

Abstract

An in vitro synergism between different inducers of AML cell differentiation has been previously observed. Therefore, we treated 53 myelodysplastic (MDS) patients with a low dose combination of cis-retinoic acid (cRA, 20-40 mg/day) and 1,25 alpha (OH)2 cholecalciferol [(OH)2D3, 1-1.5 micrograms/day] +/- intermittent 6-thioguanine (30 mg/m2/day). The latter was reserved for patients with bone marrow (BM) blast excess (> or = 5%). The treatment was well tolerated, without major toxicity. Among 25 patients with BM blasts less than 5%, we observed one complete, eight partial and four minor responses (response rate 52%) with a median response duration of 8 months (2 +/- 24). Median survival, which did not correlate with response, is projected at 76 months. Thirty-one patients with BM blast excess (> or = 5%), including three of the previous group who progressed to refractory anemia with excess of blasts (RAEB), were treated with the three-drug protocol. One complete, 12 partial and six minor responses were obtained (response rate 61%) with a median response duration of 6 months (2-29+). A significant difference in survival (P < 0.005) was observed between the 19 responders (median 25 months) and the 12 non-responders (median 9 month...Continue Reading

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Citations

Apr 3, 1998·Journal of Cellular Physiology·C GrégoireI Maridonneau-Parini
May 1, 1997·Trends in Neurosciences·L G Wu, P Saggau
Aug 28, 2007·Nature Reviews. Cancer·Kristin K DeebCandace S Johnson
Sep 30, 1998·British Journal of Haematology·V Santini, P R Ferrini
Feb 18, 2009·Blood·Daniel NowakH Phillip Koeffler
Jun 20, 2013·Nutrients·Aric C Hall, Mark B Juckett
Nov 11, 2010·Annals of the New York Academy of Sciences·Aaron J WeissJeffrey I Mechanick
Jul 22, 2004·Experimental Cell Research·Michael Danilenko, George P Studzinski
Aug 1, 1997·Disease-a-month : DM·P Jacobs
Dec 24, 2011·Cancer Letters·Minji KimMaurizio Chiriva-Internati
May 18, 2016·International Journal of Molecular Sciences·Ewa MarcinkowskaGeoffrey Brown
Feb 9, 2017·Experimental Hematology·Huynh CaoChien-Shing Chen

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