Combined diphtheria-tetanus-pertussis vaccine for tetanus-prone wound management in adults

European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine
Terje HoelLode M Schuerman

Abstract

Booster vaccination against tetanus, diphtheria and pertussis is recommended throughout life. Adults are difficult to reach and vaccination coverage in this group is often inadequate. The use of a reduced-antigen content combined diphtheria-tetanus-acellular pertussis ('adult' dTpa) vaccine for tetanus prophylaxis in emergency room wound management provides an opportunity to boost immunity against three infections simultaneously, thereby optimizing the efficiency of medical interventions with adults assessed. A single-blind, randomized, controlled study of 320 healthy adults, the anti-tetanus antibody response within 10 days following vaccination with Boostrix (reduced-antigen diphtheria-tetanus-acellular pertussis). The anti-tetanus antibody response to the reduced-antigen diptheria-tetanus-acellular pertussis vaccine was equivalent to Tetavax, a licensed monovalent tetanus-toxoid vaccine. The use of diphtheria-tetanus-acellular pertussis is a safe and effective way to provide vaccination to adults against three diseases during emergency room visits for wound management.

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Citations

May 24, 2011·The Lancet Infectious Diseases·Fred ZeppPierre Van Damme
Apr 29, 2016·Human Vaccines & Immunotherapeutics·Olivier Van Der MeerenAndrew F Trofa
Jun 10, 2016·Clinical and Experimental Immunology·B Weinberger
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Sep 15, 2017·Wiener medizinische Wochenschrift·Ursula Kunze, Ernest Groman

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