Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk

BMC Cancer
Ummiye V OnayHilmi Ozcelik

Abstract

Estrogens are crucial tumorigenic hormones, which impact the cell growth and proliferation during breast cancer development. Estrogens are metabolized by a series of enzymes including COMT, which converts catechol estrogens into biologically non-hazardous methoxyestrogens. Several studies have also shown the relationship between estrogen and cell cycle progression through activation of CCND1 transcription. In this study, we have investigated the independent and the combined effects of commonly occurring CCND1 (Pro241Pro, A870G) and COMT (Met108/158Val) polymorphisms to breast cancer risk in two independent Caucasian populations from Ontario (1228 breast cancer cases and 719 population controls) and Finland (728 breast cancer cases and 687 population controls). Both COMT and CCND1 polymorphisms have been previously shown to impact on the enzymatic activity of the coded proteins. Here, we have shown that the high enzymatic activity genotype of CCND1High (AA) was associated with increased breast cancer risk in both the Ontario [OR: 1.3, 95%CI (1.0-1.69)] and the Finland sample [OR: 1.4, 95%CI (1.01-1.84)]. The heterozygous COMTMedium (MetVal) and the high enzymatic activity of COMTHigh (ValVal) genotype was also associated with br...Continue Reading

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Citations

May 29, 2008·JAMA : the Journal of the American Medical Association·Linda M DongUlrike Peters
Sep 27, 2008·Breast Cancer Research and Treatment·Cheng LuHongbing Shen
Nov 27, 2009·Breast Cancer Research and Treatment·Sujee JeonDaehee Kang
Feb 5, 2010·Breast Cancer Research and Treatment·Haixia DingZhanwei Wang
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Nov 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·XiaoRui LiXiaoChun Kang
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Dec 23, 2016·Pathology Oncology Research : POR·Zahra SoleimaniYounes Aftabi

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Methods Mentioned

BETA
genotyping

Software Mentioned

SigmaPlot
QUANTO
PEPI
Review Manager ( RevMan

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