Combined effect of diabetes and frailty on mortality and incident disability in older Japanese adults

Geriatrics & Gerontology International
Akihiko KitamuraS Shinkai

Abstract

Evidence is limited on how frailty affects the association between diabetes and adverse outcomes at the population level. The present community-based study aimed to clarify the relative risks of death and disability in older Japanese adults with diabetes, frailty, both or neither. The present prospective study analyzed data from 1271 Japanese residents aged ≥65 years in Kusatsu town in Gunma Prefecture, Japan, who participated in annual health checkups carried out between 2002 and 2011, and were initially free of disability. A Cox proportional hazards regression model was used to identify associations of diabetes and frailty with all-cause mortality and incident disability. Among the 1271 participants, 176 (14%) had diabetes (mean hemoglobin A1c 7.5%, body mass index 24.2 kg/m2 , 45% using diabetes medications) and 151 (12%) had frailty at baseline. Compared with non-frail participants without diabetes, those with diabetes and frailty had higher risks of mortality (multivariable hazard ratio 5.0, 95% CI 2.4-10.3) and incident disability (hazard ratio 3.9, 95% CI 2.1-7.3). In contrast, non-frail participants with diabetes did not have a significantly increased risk of mortality, although they had a higher tendency for the incide...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jul 1, 1991·Journal of Geriatric Psychiatry and Neurology·W J BurkeS P Wengel
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Jan 5, 2002·Diabetes Care·Edward W GreggUNKNOWN Study of Osteoporotic Fractures Research Group
Mar 4, 2005·Journal of the American Geriatrics Society·Takako Tsutsui, Naoko Muramatsu
Jan 21, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stefano VolpatoJack M Guralnik
Oct 25, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·José Alberto Avila-FunesJean-François Dartigues
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
May 28, 2009·JAMA : the Journal of the American Medical Association·Juliana C N ChanFrank B Hu
Dec 8, 2009·Diabetes Research and Clinical Practice·Nigel UnwinDavid Whiting
Jun 12, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·R E HubbardK Rockwood
Jun 4, 2011·Diabetes Care·Neda LaiteerapongElbert S Huang
Jun 27, 2012·Acta Diabetologica·Francesco CacciatorePasquale Abete
Feb 4, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yu TaniguchiYoshinori Fujiwara
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Evelyn WongAnna Peeters
Feb 20, 2012·Journal of Diabetes Investigation·Atsunori KashiwagiUNKNOWN Committee on the Standardization of Diabetes Mellitus‐Related Laboratory Testing of Japan Diabetes Society
May 20, 2015·International Journal of Nursing Studies·Shu-Fang Chang, Pei-Ling Lin
Jul 4, 2015·Journal of the American Medical Directors Association·Ying LiBirong Dong
Dec 24, 2015·Diabetes Care·UNKNOWN American Diabetes Association
Mar 29, 2016·Geriatrics & Gerontology International·Shoji ShinkaiYoshinori Fujiwara
Aug 30, 2016·Journal of the American Medical Directors Association·Anthony Liccini, Theodore K Malmstrom
Sep 8, 2016·Journal of the American Medical Directors Association·Marta Castro-RodríguezL Rodríguez-Mañas

❮ Previous
Next ❯

Citations

Nov 27, 2020·Journal of Cachexia, Sarcopenia and Muscle·Akihiko KitamuraShoji Shinkai
Feb 13, 2021·Geriatrics & Gerontology International·Sayuri Sable-MoritaHidenori Arai
Apr 13, 2021·Journal of Epidemiology·Mari YamashitaShoji Shinkai
May 23, 2021·International Journal of Nursing Studies·Ling-Na KongShuo-Zhen Chen
Jul 15, 2021·Revista brasileira de enfermagem·Sarah Caroline Oliveira de Souza BoitragoFernanda Marques da Costa
Dec 7, 2021·Frontiers in Endocrinology·Simone PaterniFabio Monzani

❮ Previous
Next ❯

Software Mentioned

spss Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.