Combined effect of HEDTA and selenium against aluminum induced oxidative stress in rat brain

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Sadhana Shrivastava

Abstract

Aluminium (Al) is a potent neurotoxin and has together with other metals been suggested to be associated with Alzheimer's disease causality. The current study was carried out to investigate the potential role of N(2-hydroxyethyl) ethylenediamine triacetic acid (HEDTA) and Se in combination against Al induced toxicity. Animals were exposed to Al at a dose of 27 mg/kg/d i.p. for 60 days. HEDTA and Se were administered at a dose of 20mg/kg/d i.p. and 0.5mg/kg/d orally, respectively for 7 consecutive days. Induction of oxidative stress was recorded in the brain after Al exposure. Significant decrease was found in the levels of reduced glutathione activities of the enzymes glutathione reductase, glutathione peroxidase, catalase, superoxide dismutase, acetyl cholinesterase, and increased levels were observed in LPO and glutathione-S-transferase activity in brain and serum. These parameters responded positively to therapy with HEDTA, but more pronounced beneficial effects were observed when HEDTA was administered in combination with Se. The combination was effective in reducing the concentration of Al and level of DNA damage.

References

Jul 1, 1976·Analytical Biochemistry·J E Brehe, H B Burch
Mar 24, 2004·Free Radical Biology & Medicine·Christopher Exley
Mar 31, 2005·Nutrition·Terken BaydarGonul Sahin
May 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Al-Sayeda A NewairyMokhtar I Yousef
May 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mokhtar I Yousef, Afrah F Salama
May 14, 2009·Journal of Environmental Monitoring : JEM·Michael Aschner
Jun 10, 2009·Journal of Ethnopharmacology·Syed Waseem BihaqiManisha Tiwari
Jun 23, 2009·Toxicology Letters·Stella MahieuNéstor Millen
Jul 3, 2009·Chemosphere·Luciane Almeri TabaldiFernando Teixeira Nicoloso
Jan 14, 2010·Brain Research Bulletin·Ivana D StevanovićMilica Ninković

❮ Previous
Next ❯

Citations

Feb 20, 2013·Molecular Neurobiology·Neha Singla, D K Dhawan
Sep 23, 2014·BioMed Research International·Alessandro FulgenziMaria Elena Ferrero
Aug 29, 2014·Biological Trace Element Research·Ihcene BouaslaAbdelfattah El Feki
Oct 1, 2020·Environmental Science and Pollution Research International·Supriya SharmaFaheem Hyder Pottoo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amoebiasis

Amoebiasis, infection by the protozoan parasite Entamoeba histolytica, remains a global health problem, despite the availability of effective treatment. Here is the latest research.