Combined effect of IL-17 and blockade of nitric oxide biosynthesis on haematopoiesis in mice

Acta Physiologica
A KrsticD Bugarski

Abstract

The study was undertaken to extend our investigation concerning both the in vivo activity of interleukin (IL)-17 and the specific role of nitric oxide (NO) in IL-17-induced effects in the process of haematopoiesis. CBA mice were simultaneously treated with IL-17 and/or nitric oxide synthase (NOS) inhibitor, l-NAME, for 5 days and changes within various haematopoietic cell lineages in bone marrow, spleen and peripheral blood were analysed. Findings showed that administration of both IL-17 and l-NAME stimulated increase in net haematopoiesis in normal mice. IL-17-enhanced myelopoiesis was characterized by stimulation of both femoral and splenic haematopoietic progenitor cells and morphologically recognizable granulocytes. Additionally, IL-17 induced alterations in the frequency of erythroid progenitor cells in both bone marrow and spleen, accompanied with their mobilization to the peripheral blood. As a consequence of these changes in the erythroid cell compartments, significant reticulocytosis was observed, which evidenced that in IL-17-treated mice effective erythropoiesis occurred. Exposure of mice to NOS inhibitor also increased the number of both granulocyte-macrophage and erythroid progenitors in bone marrow and spleens, an...Continue Reading

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Citations

Mar 7, 2012·Immunologic Research·Aleksandra KrsticDiana Bugarski
Jun 15, 2013·Cell Biology International·Jelena KrstićDiana Bugarski
Jun 1, 2016·Frontiers in Immunology·Adriana BonomoAlex Balduino
Mar 8, 2020·Histochemistry and Cell Biology·Sanja Vignjević PetrinovićVladan Čokić
Mar 6, 2013·Biological Research for Nursing·Mary Dawn HennessyBradley E Aouizerat

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