Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study.

Diabetes
Colin N A PalmerRoberto Pola

Abstract

We have previously observed that genetic profiles determined by the combination of five functionally significant single nucleotide polymorphisms (SNPs) (rs1800795, rs5498, rs5361, rs1024611, and rs679620) of genes encoding prototypical inflammatory molecules are associated with history of ischemic stroke. Here we tested the ability of this multigenic model to predict stroke risk in a large population-based prospective cohort of subjects with type 2 diabetes. This study was conducted using a prospective cohort of individuals with type 2 diabetes participating in the Go-DARTS (Genetics of Diabetes Audit and Research in Tayside Scotland) study, which includes genetic and clinical information of patients with diabetes within the Tayside region of Scotland, U.K. The above-mentioned inflammatory SNPs were investigated in 2,182 Go-DARTS participants. We created an inflammatory risk score (IRS), ranging from 0 to 5, according to the number of "at-risk" genotypes concomitantly carried by a given individual. The primary outcome was the occurrence of fatal or nonfatal stroke of any kind. Mean follow-up time was 6.2 ± 1.1 years. The incidence of stroke increased according to the IRS. The IRS was significantly and independently associated w...Continue Reading

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Citations

Feb 16, 2013·BMC Medical Genetics·Lena DörhöferUNKNOWN DIACORE Study Group
Mar 29, 2011·Expert Review of Cardiovascular Therapy·Takafumi TsuchiyaMasatomo Mori
Mar 17, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Helena MansoAstrid M Vicente
Jul 15, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Zhongyang HuDeren Hou
Oct 13, 2017·International Journal of Epidemiology·Harry L HébertColin N A Palmer

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