Combined effect of polarity and pH on the chromatographic behavior of some angiotensin II receptor antagonists and optimization of their determination in pharmaceutical dosage forms

Journal of Pharmaceutical and Biomedical Analysis
Ebru Cubuk DemiralayGuleren Alsancak

Abstract

In the present study, the combined effect of mobile phase polarity and pH on retention behavior of some ARA-IIs (irbesartan, losartan, valsartan and telmisartan) is investigated. The linear relationships established between retention factors of the species and the polarity parameter of the mobile phase has proved to predict accurately retention in LC as a function of the acetonitrile content (50%, 55%, 60%, v/v). The suggested model uses the pH value in the acetonitrile-water mixture as mobile phase instead of pH value in water and takes into account the effect of activity coefficients. Moreover, correlation between retention and the mobile phase pH can be established allowing prediction of the retention behavior as a function of the mobile phase pH. The model can be used to estimate the pKa in an acetonitrile percentage between 50% and 60%, at 30 degrees C. The developed method was successfully applied to both the simultaneous separation of these drug-active compounds and individual determination in their commercial pharmaceutical dosage forms.

References

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Citations

Jun 26, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·R Nageswara RaoR Mastan Vali
Jun 4, 2015·Biopharmaceutics & Drug Disposition·Helene ChapyOlivier Nicolas
Aug 17, 2014·International Journal of Pharmaceutics·Chutimon MuankaewThorsteinn Loftsson
Aug 21, 2012·Journal of Pharmaceutical and Biomedical Analysis·Ebru Çubuk DemiralayCansel Cakır
Mar 20, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zorica VujićPredrag Stankovic
Jun 8, 2021·Journal of Pharmaceutical Sciences·Saikishore MeruvaSumit Kumar

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