Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disorders

PloS One
José OliveiraRyad Tamouza

Abstract

Gene-environment interactions may play an important role in modulating the impact of early-life stressful events on the clinical course of bipolar disorder (BD), particularly associated to early age at onset. Immune dysfunction is thought to be an important mechanism linking childhood trauma with early-onset BD, thus the genetic diversity of immune-related loci may account for an important part of the interindividual susceptibility to this severe subform. Here we investigated the potential interaction between genetic variants of Toll-like receptors 2 (TLR2) and 4 (TLR4), major innate immune response molecules to pathogens, and the childhood trauma questionnaire (CTQ) in age at onset of BD. We recruited 531 BD patients (type I and II or not otherwise specified), genotyped for the TLR2 rs4696480 and rs3804099 and TLR4 rs1927914 and rs11536891 single-nucleotide polymorphisms and recorded for history of childhood trauma using the CTQ. TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, physical and sexual abuses were evaluated in relation to age at onset as defined by the age at first manic or depressive episode. We observed a combined effect of TLR2 rs3804099 TT genotype and reported sexual abuse on deter...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Jun 1, 1978·Neuropharmacology·P BechT G Bolwig
Aug 1, 1994·The American Journal of Psychiatry·D P BernsteinJ Ruggiero
Jul 1, 1997·Psychological Medicine·M B SteinB McClarty
Aug 15, 2003·International Immunology·Hye-Seong MunAkihiko Yano
Mar 12, 2004·Biological Psychiatry·Faith B DickersonRobert H Yolken
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie K Olson, Stephen D Miller
Oct 8, 2004·Santé mentale au Québec·Daniel PaquetteMark Zoccolillo
Mar 15, 2005·Bipolar Disorders·Marion LeboyerFrank Bellivier
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rajagopal N AravalliJames R Lokensgard
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
May 17, 2006·Critical Reviews in Immunology·Samantha L BaileyStephen D Miller
Jan 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andrea DaneseRichie Poulton
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Françoise Debierre-GrockiegoRalph T Schwarz
Aug 21, 2007·Nature Cell Biology·Asya RollsMichal Schwartz
Sep 1, 2007·Behavioural Pharmacology·Benicio N FreyFlávio Kapczinski
Sep 22, 2007·Genes, Brain, and Behavior·N PerroudA Malafosse
Mar 20, 2008·JAMA : the Journal of the American Medical Association·Elisabeth B BinderKerry J Ressler
Jan 20, 2009·Biological Psychiatry·Tania L RothJ David Sweatt
May 23, 2009·Nature Reviews. Immunology·Serge Rivest
Jul 15, 2009·Bipolar Disorders·Bruno EtainMarion Leboyer
May 14, 2010·Pediatric Research·Asmaa Abu-MaziadJeffrey C Murray
Jun 30, 2010·The Journal of Clinical Psychiatry·Jeanette M JerrellAvnish Tripathi
Oct 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Linda L CarpenterLawrence H Price
Nov 19, 2010·American Journal of Preventive Medicine·Janet W Rich-EdwardsRosalind J Wright
Dec 31, 2010·The Journal of Clinical Psychiatry·Marion Leboyer, David J Kupfer
Feb 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anja HennMarcel Leist
Jul 8, 2011·Nature·Pamela Y CollinsDan J Stein
Nov 2, 2011·Journal of Child and Adolescent Psychopharmacology·Benjamin I GoldsteinBoris Birmaher
Dec 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shirong LiuKlaus Fassbender

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Citations

Feb 2, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ji Sun Kim, Seung-Hwan Lee
Jan 23, 2016·Brain, Behavior, and Immunity·Andrea WieckMoisés Evandro Bauer
Jan 15, 2016·International Journal of Bipolar Disorders·Monica AasBruno Etain
Mar 19, 2016·Psychopharmacology·Marion LeboyerLaurent Groc
Sep 19, 2015·Current Psychiatry Reports·Nils C Westfall, Charles B Nemeroff
Sep 30, 2015·Psychopharmacology·Yi-Yung HungTiao-Lai Huang
Aug 9, 2016·Psychiatry and Clinical Neurosciences·Fanny Aldinger, Thomas G Schulze
Jan 12, 2017·Pathogens·Claudia Del GrandeFabrizio Bruschi
Dec 14, 2018·Pharmacological Reports : PR·Paulina Jaworska-Andryszewska, Janusz K Rybakowski
Jan 8, 2020·Molecular Psychiatry·Francis James A Gordovez, Francis J McMahon
Jul 1, 2017·Current Psychiatry Reports·Marija Mitkovic VoncinaDusica Lecic Tosevski
Sep 6, 2018·Therapeutic Advances in Psychopharmacology·Tobias A Rowland, Steven Marwaha
Aug 24, 2017·Acta Psychiatrica Scandinavica·J OliveiraM Leboyer
Jul 20, 2016·Neuroscience Bulletin·Philippe Leff-GelmanDavid Ellioth Pulido-Ascencio
Jun 6, 2018·Acta Psychiatrica Scandinavica·R TamouzaM Leboyer
Oct 9, 2020·Bipolar Disorders·Sorcha BoltonKate E A Saunders
Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Gabriel R FriesJoao Quevedo

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