PMID: 11926611Apr 3, 2002Paper

Combined effects of acetaminophen, isopropylantipyrine and caffeine on pregnant and nonpregnant liver

Human & Experimental Toxicology
F BurdanZ Urbanowicz

Abstract

The common effects of acetaminophen (APA), isopropylantipyrine (IPA) and caffeine on liver were examined in rats. The preparations were given in Tween-80 solution once daily, in a constant proportion of 5:3:1, during days 8 to14 of gestation (S1, S2, S3 groups) or between days 8 and 14 of the experiment in nonpregnant female Wistar rats (S1-NP, S2-NP, S3-NP groups). The administration was in three different doses: doses S1, S1-NP-3.5 mg/kg APA, 2.14 mg/ kg IPA, 0.7 mg/kg caffeine; doses S2, S2-NP were 10 times higher; and doses S3, S3-NP 100 times higher than doses S1, S1-NP There were two control groups (T, T-NP) with Tween-80. At day 21 of gestation/experiment blood was taken for determination of activity of alanine (ALA) and aspartate (AST) aminotransferase, lactate (LDH) and glutamate (GLDH) dehydrogenase, levels of bilirubin (BIL), urea (URE), total protein (TP) and thymol turbidity test (TTT). The liver sections were examined by light microscopy with four stains: hematoxylin and eosin (H+E), silver Gomori, van Gieson and periodic acid-Schiff (PAS). There was a statistically significant (P<0.05) increase in the GLDH (S3-NP, S2, S3 groups) and AST, LDH (S3 group) activity, a decrease in URE (S2, S3 groups) and decrease in T...Continue Reading

References

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Citations

Jul 10, 2003·Reproductive Toxicology·Franciszek BurdanLidia Klepacz
Mar 4, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert L BrentRobert M Diener
Oct 2, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Franciszek BurdanLidia Klepacz
Jul 28, 2010·Reproductive Toxicology·Anthony R ScialliMike A Royal

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